Linezolid in the treatment of multidrug-resistant/extensively drug-resistant tuberculosis in paediatric patients: Experience of a paediatric infectious diseases unit

• Published in: Scandinavian journal of infectious diseases Vol. 43; no. 6-7; pp. 556 - 559
• Main Authors: Kjöllerström, Paula, Brito, Maria João, Gouveia, Catarina, Ferreira, Gonçalo, Varandas, Luís
• Format: Journal Article
• Language: English
• Published: Colchester Informa Healthcare 01.07.2011; Informa
• Subjects: Acetamides - administration & dosage; Adolescent; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antitubercular Agents - administration & dosage; Bacterial diseases; Biological and medical sciences; Child; Child, Preschool; Drug Therapy, Combination - methods; Extensively Drug-Resistant Tuberculosis - drug therapy; Female; Human bacterial diseases; Humans; Infectious diseases; Linezolid; Male; Medical sciences; Oxazolidinones - administration & dosage; Pharmacology. Drug treatments; Treatment Outcome; Tuberculosis and atypical mycobacterial infections; Human; Linezolid; Microbiology; Mycobacterial infection; Infection; Antibiotic; Treatment; Tuberculosis; Oxazolidinone derivative; Multiple resistance; Bacteriosis; Protein synthesis inhibitor; Antibacterial agent; Oxazole derivatives; Child; Oxazolidinedione derivatives
• ISSN: 0036-5548; 1651-1980
• DOI: 10.3109/00365548.2011.564649

Abstract Linezolid has been used in the treatment of multidrug-resistant/extensively drug-resistant tuberculosis in adults with encouraging results, however experience in children is scarce. We describe our experience with the use of linezolid as part of a multidrug regimen in the treatment of 4 patients who had persistent positive cultures, despite prolonged combined therapy.