Mitochondrial DNA mutations, oxidative stress, and aging

Advances in understanding of mitochondrial physiology and genetics in relation to pathology have exploded in the last decade. Paralleling this increase has been an active debate about the role of mitochondrial oxidative stress with regard to mitochondrial DNA mutations, aging, and disease. We discus...

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Published inMechanisms of Ageing and Development Vol. 122; no. 14; pp. 1577 - 1589
Main Authors Golden, Tamara.-R, Melov, Simon
Format Book Review Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 30.09.2001
Elsevier Science
Subjects
Aging
Aging - genetics
Animals
Biological and medical sciences
Development. Metamorphosis. Moult. Ageing
DNA, Mitochondrial - physiology
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease - genetics
Humans
Mitochondrial DNA
Mutation
Oxidative stress
Oxidative Stress - physiology
Somatic mutations
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Aging
Oxidative stress
Mitochondrial DNA
Somatic mutations
Human
Mitochondria
Senescence
Disease
Etiology
Animal
Review
Mutation
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Summary:Advances in understanding of mitochondrial physiology and genetics in relation to pathology have exploded in the last decade. Paralleling this increase has been an active debate about the role of mitochondrial oxidative stress with regard to mitochondrial DNA mutations, aging, and disease. We discuss in a historical context the rapid progress in our understanding of the role of mitochondrial DNA mutations in disease, mitochondrial oxidative stress in aging, and the potential interplay between these two phenomena.
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ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(01)00288-3