Successful management of endodermal sinus tumor of the ovary associated with pregnancy

• Published in: Gynecologic oncology Vol. 88; no. 3; pp. 447 - 450
• Main Authors: Shimizu, Yoshihiko, Komiyama, Shin-ichi, Kobayashi, Toru, Nakata, Kouichi, Iida, Toshihiko
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.03.2003; Elsevier
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Bleomycin - administration & dosage; Chemotherapy; Cisplatin - administration & dosage; Diseases of mother, fetus and pregnancy; Endodermal sinus tumor; Endodermal Sinus Tumor - drug therapy; Etoposide - administration & dosage; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Ovarian Neoplasms - drug therapy; Pregnancy; Pregnancy Complications, Neoplastic - drug therapy; Pregnancy. Fetus. Placenta; Tumors; Asia; Japan; Pregnancy; Endodermal sinus tumor; Chemotherapy; Germ cell tumor; Case study; Human; Ovarian diseases; Ovary; Association; Female; Malignant tumor; Female genital diseases
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/S0090-8258(02)00075-6

Pregnancy complicated by endodermal sinus tumor of the ovary has rarely been reported. A 32-year-old pregnant woman was found to have an ovarian tumor. At 19 weeks of gestation, tumorectomy was performed and a diagnosis of primary endodermal sinus tumor of the ovary (stage Ic) was made. Pregnancy was continued without postoperative chemotherapy. At 36 weeks of gestation, she underwent cesarean section combined with second-look laparotomy. A normal infant was delivered and there were no signs of recurrence. Subsequently, three courses of combination chemotherapy with bleomycin, etoposide, and cisplatin were administered. There was no evidence of recurrence at 27 months after initial treatment. Successful management of endodermal sinus tumor of the ovary in a pregnant woman is reported.