Gadolinium-containing contrast media for radiographic examinations: a position paper

• Published in: European radiology Vol. 12; no. 10; pp. 2600 - 2605
• Main Authors: Thomsen, Henrik S, Almèn, Torsten, Morcos, Sameh K
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.10.2002
• Subjects: Animals; Committees; Contrast agents; Contrast Media - adverse effects; Contrast Media - chemistry; Gadolinium - adverse effects; Gadolinium - chemistry; Gadolinium DTPA - adverse effects; Gadolinium DTPA - chemistry; Humans; Iodine; Kidney Diseases - chemically induced; Lethal Dose 50; Patients; Pharmacokinetics; Rabbits; Radiography; Radiology; Swine; Thyroid gland; Toxicity; X-rays; Denmark; Italy; Sweden; United Kingdom > UK; France; Norway
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-002-1628-3

Recently, it has been suggested that gadolinium-based contrast media could be used for radiological examinations in patients with significant renal impairment, previous severe generalized reaction to iodinated contrast media or thyroid disease about to undergo radioactive iodine treatment; however, the indications for and risks of using gadolinium agents in this way are not well known; hence, the Contrast Media Safety Committee of The European Society of Urogenital Radiology reviewed the literature to issue a position paper on this subject. A comprehensive literature review was performed and the resulting report was discussed at the Ninth European Symposium on Urogenital Radiology in Genoa, Italy, June 2002. Review of the literature indicates that according to experimental data on animals gadolinium-based contrast media have more nephrotoxic potential than iodinated contrast media in equivalent X-ray attenuating doses; therefore, gadolinium-based contrast media should not replace iodinated contrast media in patients with renal insufficiency for radiographic examinations. For patients with previous severe generalized reactions to iodinated contrast media, and in patients about to undergo thyroid treatment with radioactive iodine gadolinium-based contrast media in approved intravenous doses, up to 0.3 mmol/kg body weight will not give diagnostic radiographic information in most cases. Gadolinium-based contrast media are not approved for radiographic examinations.