Gray–white matter discrimination—a possible marker for brain damage in heat stroke?

• Published in: European journal of radiology Vol. 43; no. 1; pp. 1 - 5
• Main Authors: Szold, Oded, Reider-Groswasser, Irith I., Abraham, Ron Ben, Aviram, Galit, Segev, Yoram, Biderman, Philippe, Sorkine, Patrick
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.07.2002; Elsevier Science
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Brain - diagnostic imaging; Brain - pathology; Coma; Computerized tomography; Emergency and intensive care: comas and nervous system diseases; Female; Gray–white matter; Heat stroke; Heat Stroke - diagnostic imaging; Heat Stroke - pathology; Humans; Intensive care medicine; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nervous system; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Tomography, X-Ray Computed; Coma; Gray–white matter; Computerized tomography; Heat stroke; Human; Nervous system diseases; Prognosis; Radiodiagnosis; Malignant hyperthermia; Radiologic sign; Grey matter; Stage classification; White matter; Cerebral disorder; Sensitivity; Encephalopathy; Cohort study; Central nervous system disease; Medical imagery; Computerized axial tomography; Diagnosis; Brain (vertebrata)
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/S0720-048X(01)00467-3

Introduction/objective: Heat stroke (HS) is a common medical emergency which carries high morbidity and morality. This study was designed to describe the pattern of central nervous system (CNS) changes as detected by brain CT scan in a case series of six patients suffering from classical and exertional HS. Methods and patients: All the patients were admitted in critical condition during the heat wave in the summer of 1999 in Israel. Each was in deep coma with a measured core temperature of over 40 °C upon admission to the emergency department. Results: Aggressive cooling measures decreased the core temperature to <38 °C within 30 min following admission. Two patients (33.3%) died. One of the survivors remained in a vegetative state. Brain CT studies carried out within 4 days of admission in all the patients revealed severe loss of gray–white matter discrimination (GWMD) without signs of acute bleed or significant focal lesion, findings that persisted in repeated brain CTs in one patient who remained in a vegetative state. Discussion and conclusions: Loss of GWMD may represent an early and sensitive indication of severe brain damage in patients with severe HS. Further studies in larger groups of patients are warranted in order to determine whether the appearance of GWMD in brain CTs of patients with HS has prognostic value.