Classical dopamine agonists

The pioneering work of Arvid Carlsson has laid the foundation for a number of innovative therapies for severe central nervous system (CNS) diseases. He was awarded the Nobel Price for the discovery of the crucial role of dopamine (DA) as a neurotransmitter in the CNS, thereby forming the basis for t...

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Bibliographic Details
Published inJournal of Neural Transmission Vol. 126; no. 4; pp. 449 - 454
Main Authors Horowski, R., Löschmann, P.-A.
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.04.2019
Subjects
Medicine
Medicine & Public Health
Neurology
Neurology and Preclinical Neurological Studies - Review Article
Neurosciences
Psychiatry
Lisuride
Bromocriptine
Apomorphine
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Summary:The pioneering work of Arvid Carlsson has laid the foundation for a number of innovative therapies for severe central nervous system (CNS) diseases. He was awarded the Nobel Price for the discovery of the crucial role of dopamine (DA) as a neurotransmitter in the CNS, thereby forming the basis for the symptomatic therapy of Parkinson’s disease (PD) with l -DOPA and subsequently dopaminergic drugs. Parenteral apomorphine has a short lasting effect in PD, bromocriptine can be administered orally and has a long-lasting effects but is poorly tolerated. Lisuride on the other hand has a high affinity to DA receptors and can be administered orally, parenterally or via the transdermal route of administration. Last but not least Carlsson developed the concepts of presynaptic effects of DA agonists as well as DA partial agonism potentially innovative mechanisms for treatment of PD and schizophrenia.
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ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-019-01989-y