Prevalence of latent autoimmune diabetes of adults (LADA) in Southern Spain

• Published in: Diabetes research and clinical practice Vol. 56; no. 3; pp. 213 - 220
• Main Authors: Soriguer-Escofet, Federico, Esteva, Isabel, Rojo-Martinez, Gemma, Ruiz de Adana, Soledad, Catalá, Marieta, Merelo, M.José, Aguilar, Manuel, Tinahones, Francisco, Garcı́a-Almeida, José M., Gómez-Zumaquero, Juan M., Cuesta-Muñoz, Antonio L., Ortego, José, Freire, José M.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.2002; Elsevier Science
• Subjects: Adolescent; Adult; Analysis. Health state; Autoantibodies - blood; Autoimmune Diseases - epidemiology; Autoimmune Diseases - immunology; Biological and medical sciences; Blood Glucose - metabolism; Cross-Sectional Studies; Diabetes mellitus; Diabetes Mellitus - epidemiology; Diabetes Mellitus - immunology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; General aspects; Glucose Tolerance Test; Glutamate Decarboxylase - immunology; Humans; Insulin Antibodies - blood; Islet autoantibodies; LADA; Medical sciences; Middle Aged; Prevalence; Protein Tyrosine Phosphatases - immunology; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reference Values; Reproducibility of Results; Spain - epidemiology; Europe; Spain; LADA; Islet autoantibodies; Prevalence; Diabetes mellitus; Endocrinopathy; Human; Immunopathology; Correlation; Autoimmune disease; Glucose tolerance test; Medical screening; Epidemiology; Glutamic acide decarboxylase antibody; Cross sectional study; Insulin dependent diabetes; Insulinoresistant diabetes; Adult; Clinical investigation; Islet cell antibody; Impaired glucose tolerance; Age; Glycemia
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/S0168-8227(02)00002-5

Objective: To study the prevalence of diabetes mellitus and islet autoantibodies in an adult population from Southern Spain. Research design and methods: A cross-sectional study in Southern Spain of 1226 people, age 18–65 years. Clinical data were obtained and a blood sample taken to measure autoantibodies (glutamic acid decarboxylase antibodies (GADAb), tyrosine phosphatase antibodies (IA2Ab), and insulin antibodies (IAA)). An oral glucose tolerance test (OGTT) was also given to 982 of the subjects. Results: The overall prevalence of diabetes mellitus according to the WHO 1979 criteria was 10.9% and according to the ADA 1997 criteria it was 14.7% (8.8% were unaware of their diabetes). The prevalence of impaired fasting glucose (IFG) was 12.4% and of impaired glucose tolerance (IGT) 11.5%. The prevalence of GADAb+ in the general population was 0.9% and in the diabetic population 3.7%. There were no significant differences between groups in the prevalence of IA2Ab or IAA (both were 0.8% in the general population). Of the three autoantibodies studied, only GADAb were significantly different in the diabetic population ( P=0.0006). Conclusions: The prevalence of Type 2 diabetes and LADA are high in the south of Spain