17-Hydroxylase: an evaluation of the present view of its catalytic role in steroidogenesis
This survey analyses the evidence that has led to the belief that the catalytic role of 17-hydroxylase in the biosynthesis of cortisol, estradiol, testosterone and dehydroepiandrosterone is confined to two chamical reactions: pregnenolone→17-hydroxypregnenolone→dehydroepiandrosterone. This analysis...
Saved in:
Published in | Journal of Steroid Biochemistry and Molecular Biology Vol. 78; no. 4; pp. 299 - 312 |
---|---|
Main Authors | , |
Format | Book Review Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.10.2001
Elsevier Science |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | This survey analyses the evidence that has led to the belief that the catalytic role of 17-hydroxylase in the biosynthesis of cortisol, estradiol, testosterone and dehydroepiandrosterone is confined to two chamical reactions: pregnenolone→17-hydroxypregnenolone→dehydroepiandrosterone. This analysis suggests that the evidence supporting this view is not compelling enough to accept it unquestioningly. Different interpretations of the data can suggest other catalytic roles for 17-hydroxylase that are worthy of consideration. One such alternative is proposed. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
ISSN: | 0960-0760 1879-1220 |
DOI: | 10.1016/S0960-0760(01)00105-4 |