17-Hydroxylase: an evaluation of the present view of its catalytic role in steroidogenesis

This survey analyses the evidence that has led to the belief that the catalytic role of 17-hydroxylase in the biosynthesis of cortisol, estradiol, testosterone and dehydroepiandrosterone is confined to two chamical reactions: pregnenolone→17-hydroxypregnenolone→dehydroepiandrosterone. This analysis...

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Bibliographic Details
Published inJournal of Steroid Biochemistry and Molecular Biology Vol. 78; no. 4; pp. 299 - 312
Main Authors Lieberman, Seymour, Warne, Patricia A.
Format Book Review Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.2001
Elsevier Science
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Summary:This survey analyses the evidence that has led to the belief that the catalytic role of 17-hydroxylase in the biosynthesis of cortisol, estradiol, testosterone and dehydroepiandrosterone is confined to two chamical reactions: pregnenolone→17-hydroxypregnenolone→dehydroepiandrosterone. This analysis suggests that the evidence supporting this view is not compelling enough to accept it unquestioningly. Different interpretations of the data can suggest other catalytic roles for 17-hydroxylase that are worthy of consideration. One such alternative is proposed.
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ISSN:0960-0760
1879-1220
DOI:10.1016/S0960-0760(01)00105-4