Embryo aneuploidy is not impacted by selective serotonin reuptake inhibitor exposure

• Published in: Fertility and sterility Vol. 108; no. 6; pp. 973 - 979
• Main Authors: Hernandez-Nieto, Carlos, Lee, Joseph, Nazem, Taraneh, Gounko, Dmitry, Copperman, Alan, Sandler, Benjamin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2017
• Subjects: Abortion, Spontaneous - etiology; Adult; Aneuploidy; antidepressants; Antidepressive Agents - adverse effects; Antidepressive Agents - therapeutic use; Biopsy; Blastocyst - drug effects; Female; Fertility; Fertilization in Vitro; Genetic Testing; Humans; Infertility - diagnosis; Infertility - physiopathology; Infertility - therapy; in vitro fertilization; Logistic Models; Maternal Exposure - adverse effects; Odds Ratio; Pregnancy; Pregnancy Rate; Pregnancy, Multiple; Preimplantation Diagnosis - methods; preimplantation genetic screening; Retrospective Studies; Risk Assessment; Risk Factors; selective serotonin reuptake inhibitors; Serotonin Uptake Inhibitors - adverse effects; Serotonin Uptake Inhibitors - therapeutic use; Single Embryo Transfer; Treatment Outcome; Aneuploidy; antidepressants; preimplantation genetic screening; in vitro fertilization; selective serotonin reuptake inhibitors
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2017.08.040

To study whether maternal exposure to selective serotonin reuptake inhibitors (SSRIs) has any influence on rates of blastocyst aneuploidy and/or in vitro fertilization (IVF) cycle outcomes. Retrospective cohort analysis. Private and academic IVF center. Patients who underwent IVF with preimplantation genetic treatment with trophectoderm biopsy (n = 4,355 cycles) and patients who underwent a single-embryo transfer (SET) between January-2012 and June-2017 (n = 2,132 cycles). Comprehensive chromosome screening and euploid SET. Odds of embryo aneuploidy. Of 19,464 embryos analyzed, 3.9% (n = 743) were exposed to a SSRI, and the remaining 96.1% (n = 18,721) were not. The embryo euploid rate was 52.1%, and the aneuploid rate was 42.5%; 5.4% of the reports were inconclusive. No differences were found in clinical and IVF characteristics among the cohorts. After controlling for cofounders, there was no statistically significant associations between exposure to SSRIs and the odds of aneuploidy (adjusted odds ratio [OR] 0.04; 95% confidence interval [CI], −0.04–0.09). In a subanalysis including 2,132 thawed SET cycles, no differences were observed in implantation rate (71.3% vs. 70.1%; OR 0.60; 95% CI, 0.60–1.47), clinical pregnancy rate (58.2% vs. 59.7%; OR 0.70; 95% CI, 0.70–1.61), loss rate (18.5% vs. 11.49%; OR 1.54; 95% CI, 0.94–2.54), or multiple pregnancy rate (0.6% vs. 0; OR 0.7; 95% CI, 0.02–7.32) between cohorts. Patients exposed to SSRIs in vivo are not susceptible to an increased rate of embryo aneuploidy in IVF. The IVF outcomes of patients exposed to SSRIs do not differ from those of unexposed patients.