SERS-based rapid detection of 2,4-dichlorophenoxyacetic acid in food matrices using molecularly imprinted magnetic polymers

• Published in: Mikrochimica acta (1966) Vol. 187; no. 8; p. 454
• Main Authors: Xu, Yi, Hassan, Md Mehedi, Ali, Shujat, Li, Huanhuan, Chen, Quansheng
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.08.2020; Springer; Springer Nature B.V
• Subjects: Adsorption; Analytical Chemistry; Antibodies; Auxin; Biomimetics; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Dichlorophenoxyacetic acid; Drinking water; Environmental protection; Enzymes; Food; Gold; Herbicides; High performance liquid chromatography; Imprinted polymers; Microengineering; Milk; Nanochemistry; Nanoparticles; Nanotechnology; Original Paper; Polymer industry; Polymers; Raman spectra; Safety and security measures; Sensors; Water sampling; Food safety; Surface-enhanced Raman scattering; Molecular imprinting; 2,4-Dichlorophenoxyacetic acid; Magnetic nanoparticles
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-020-04408-2

In order to remove the limitations of natural antibodies or enzymes, a nano-magnetic biomimetic platform based on a surface-enhanced Raman scattering (SERS) sensor has been developed for highly sensitive capture and detection of 2,4-dichlorophenoxyacetic acid (2,4-D) in food and water samples. Magnetic-based molecular imprinted polymer nanoparticles (Mag@MIP NPs) were constructed to capture the target 2,4-D molecule via biomimetic recognition, and gold nanoparticles (Au NPs) served as SERS-based probes, which are bound to the Mag@MIP NPs by electrostatic adsorption. The as-prepared SERS-MIP sensor for sensing of 2,4-D achieved a good linear relationship with a low detection limit (LOD) of 0.00147 ng/mL within 2 h and exhibited high sensitivity. The sensor was successfully applied to detect 2,4-D in milk and tap water and achieved good recoveries ranging from 93.5 to 102.2%. Moreover, the designed sensor system exhibited satisfactory results ( p  > 0.05) compared to HPLC by validation analysis. Hence, the findings demonstrated that the proposed method has significant potential for practical application in food safety and environmental protection. Graphical abstract .