Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa

• Published in: Journal of ethnopharmacology Vol. 83; no. 1; pp. 95 - 99
• Main Authors: Kongkathip, Ngampong, Dhumma-upakorn, Prasan, Kongkathip, Boonsong, Chawananoraset, Khanittha, Sangchomkaeo, Prapasri, Hatthakitpanichakul, Som
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.11.2002; Elsevier
• Subjects: Animals; Biological and medical sciences; Cardiac contractility; Cycloeucalenol; Cycloeucalenone; General pharmacology; Heart Atria - drug effects; Male; Medical sciences; Menispermaceae; Myocardial Contraction - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytosterols - pharmacology; Phytotherapy; Plant Extracts - pharmacology; Plant Stems; Rats; Rats, Wistar; Tinospora; Tinospora crispa; Triterpene; Triterpenes - pharmacology; Thailand; Asia; Cycloeucalenone; Tinospora crispa; Menispermaceae; Cardiac contractility; Cycloeucalenol; Triterpene; Heart; Cardiotonic agent; Rat; Stem; Medicinal plant; Folk medicine; Dicotyledones; Angiospermae; Mechanism of action; Right atrium; Terpenoid; Pharmacognosy; Rodentia; Contractility; In vitro; Biological activity; Vertebrata; Mammalia; Animal; Plant origin; Myocardium; Isolation; Active ingredient; Spermatophyta; Circulatory system
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(02)00210-6

This report describes the isolation of two triterpenes from the stems of Tinospora crispa, namely, cycloeucalenol ( 1) and cycloeucalenone ( 2) for the first time. It was found that cycloeucalenol ( 1) slightly increased the right atrial force of contraction whereas it showed an initial reduction followed by sustained reduction of about 10% on the left atria of the rat in vitro. Cycloeucalenone showed slight change from the control on the right and left atrial force. These results suggest that cycloeucalenol and cycloeucalenone produced mild cardiotonic effects.