Buthus tamulus venom-induced vasosensory reflexes are mediated through efferent pathways in sympathetic and vagal parasympathetics
Present study was conducted to identify the efferents mediating the vasosensory reflexes evoked by intra-arterial (i.a.) injection of Mesobuthus tamulus (BT; 1 mg/kg) venom in the distal segment of femoral artery. Blood pressure (BP), electrocardiogram (ECG) and respiratory movements were recorded f...
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Published in | Neuroscience letters Vol. 464; no. 3; pp. 199 - 202 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
30.10.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Present study was conducted to identify the efferents mediating the vasosensory reflexes evoked by intra-arterial (i.a.) injection of
Mesobuthus tamulus (BT; 1
mg/kg) venom in the distal segment of femoral artery. Blood pressure (BP), electrocardiogram (ECG) and respiratory movements were recorded for 60
min after the i.a. injection of venom in urethane anaesthetised rats. Intra-arterial injection of venom produces immediate-tachypnoeic, intermediate-hypertensive and delayed-bradycardiac responses. Respiratory changes manifested as immediate increase (by 40%) in respiratory frequency (RF) followed by a decrease (by 40%) within 1
min and subsequent sustained increase (50%) up to 60
min. Increase in BP began after the respiratory changes, peaked (50%) at 5
min and remained at that level throughout. The decrease in heart rate (HR) began after 5
min, peaked (60%) at 10
min and recovered subsequently (40%) but remained below the initial level. In terazosin pretreated animals, the venom-induced cardiorespiratory changes were attenuated significantly. Whereas in vagotomized group, venom-induced respiratory changes and HR changes were blocked but not the BP changes. The findings suggest that the venom-induced vasosensory responses involve α
1-adrenoceptors for BP and vagal efferents for HR changes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/j.neulet.2009.08.052 |