Amphiphilic Bistable Rotaxanes

• Published in: Chemistry : a European journal Vol. 9; no. 13; pp. 2982 - 3007
• Main Authors: Jeppesen, Jan O., Nielsen, Kent A., Perkins, Julie, Vignon, Scott A., Di Fabio, Alberto, Ballardini, Roberto, Gandolfi, M. Teresa, Venturi, Margherita, Balzani, Vincenzo, Becher, Jan, Stoddart, J. Fraser
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 07.07.2003; WILEY‐VCH Verlag; Wiley
• Subjects: Chemistry; Chemistry, Multidisciplinary; electrochemistry; molecular devices; Physical Sciences; rotaxanes; Science & Technology; self-assembly; tetrathiafulvalenes; electrochemistry; RECOGNITION; BUILDING-BLOCKS; molecular devices; MOLECULAR-LEVEL MACHINES; SUPRAMOLECULAR CHEMISTRY; PYRROLO-ANNELATED TETRATHIAFULVALENES; self-assembly; ELECTRON-TRANSFER; CATENANES; rotaxanes; TRANSITION-METAL; tetrathiafulvalenes; REDOX; TEMPLATE
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.200204589

Two molecular shuttles/switches—a slow one and a fast one—in the shape of amphiphilic, bistable [2]rotaxanes have been synthesized and characterized. Both [2]rotaxanes contain a hydrophobic, tetraarylmethane and a hydrophilic, dendritic stopper. They are comprised of two π‐electron‐rich stations—a monopyrrolotetrathiafulvalene unit and a 1,5‐dioxynaphthalene moiety—which can act as recognition sites for the tetracationic cyclophane, cyclobis(paraquat‐p‐phenylene), to reside around. In addition, a model [2]rotaxane, incorporating only a monopyrrolotetrathiafulvalene unit in the rod section of the amphiphilic dumbbell component and cyclobis(paraquat‐p‐phenylene) as the ring component, has been investigated. The dumbbell‐shaped components were constructed using conventional synthetic methodologies to assemble 1) the hydrophobic, tetraarylmethane stopper and 2) the hydrophilic, dendritic stopper. Next, 3) the hydrophobic stopper was fused to the 1,5‐dioxynaphthalene moiety and/or the monopyrrolotetrathiafulvalene unit by appropriate alkylations, followed by 4) attachment of the hydrophilic stopper, once again by alkylation to give the dumbbell‐shaped compounds. Finally, 5) the [2]rotaxanes were self‐assembled by using the dumbbells as templates for the formation of the encircling cyclobis(paraquat‐p‐phenylene) tetracations. The two [2]rotaxanes differ in their arrangement of the π‐electron‐rich units, one in which the SMe group of the monopyrrolotetrathiafulvalene unit points toward the 1,5‐dioxynaphthalene moiety (2⋅4 PF6) and another in which it points away from the 1,5‐dioxynaphthalene moiety (3⋅4 PF6). This seemingly small difference in the orientation of the monopyrrolotetrathiafulvalene unit leads to profound changes in the physical properties of these rotaxanes. The bistable [2]rotaxanes were both isolated as brown solids. 1H NMR and UV‐visible spectroscopy, and electrochemical investigations, reveal the presence of both possible translational isomers at ambient temperature. As a consequence of the existence of both possible translational isomers in these bistable [2]rotaxanes, they exhibit a complex electrochemical behavior, which is further complicated by the presence of folded conformations wherein the monopyrrolotetrathiafulvalene unit is involved in an “alongside” interaction with the tetracationic cyclophane. In the molecular shuttle/switch 2⋅4 PF6 a “knob”, in the shape of the SMe group, is situated between the monopyrrolotetrathiafulvalene and the 1,5‐dioxynaphthalene recognition sites, making it possible to isolate both translational isomers (2⋅4 PF6⋅GREEN and 2⋅4 PF6⋅RED) and to investigate the kinetics of the shuttling of the cyclobis(paraquat‐p‐phenylene) tetracation between the two recognition sites. The shuttling processes, which are accompanied by clearly detectable color changes, can be followed by 1H NMR and UV‐visible spectroscopy, allowing the rate constants and energies of activation for the translation of the cyclobis(paraquat‐p‐phenylene) tetracations between the two recognition sites to be determined. In the molecular shuttle/switch 3⋅4 PF6, there is no “knob” situated between the 1,5‐dioxynaphthalene and the monopyrrolotetrathiafulvalene recognition sites, resulting in a considerably faster shuttling of the cyclobis(paraquat‐p‐phenylene) tetracation between these two sites, making the separation of the two possible translational isomers of 3⋅4 PF6 impractical. However, the shuttling of the cyclobis(paraquat‐p‐phenylene) tetracation can be followed by dynamic 1H NMR spectroscopy. At low temperatures, the major translational isomer is 3⋅4 PF6⋅RED, while 3⋅4 PF6⋅GREEN is the major isomer at higher temperature. In the bistable [2]rotaxanes shuttling of the cyclobis(paraquat‐p‐phenylene) tetracations can be driven by electrochemical oxidation of the monopyrrolotetrathiafulvalene unit. In complexes in which one of the two dumbbell stoppers is missing, electrochemical oxidation causes dethreading. A slow and a fast molecular shuttle/switch have been prepared and investigated for their solutions properties. The two [2]rotaxanes differ in their arrangement of the π‐electron‐rich units—one (shown in figure) in which the SMe group of the monopyrrolotetrathiafulvalene unit points toward the 1,5‐dioxynaphthalene moiety and the other (not shown) in which it points away from the 1,5‐dioxynaphthalene moiety. This seemingly small difference in the orientation of the monopyrrolotetrathiafulvalene unit leads to profound changes in the physical properties of these [2]rotaxanes.