Neutrophil-to-lymphocyte ratio as a predictor of outcomes for patients with hepatocellular carcinoma: A Western perspective
Background and Objectives Neutrophil‐to‐lymphocyte ratio (NLR) is simple, inexpensive, and has been proposed to be predictive in hepatocellular carcinoma (HCC) in Europe and Asia. We aimed to evaluate whether NLR at presentation in a Western center provides any prognostic value compared to other com...
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Published in | Journal of surgical oncology Vol. 109; no. 2; pp. 95 - 97 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.02.2014
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background and Objectives
Neutrophil‐to‐lymphocyte ratio (NLR) is simple, inexpensive, and has been proposed to be predictive in hepatocellular carcinoma (HCC) in Europe and Asia. We aimed to evaluate whether NLR at presentation in a Western center provides any prognostic value compared to other common prognostic scores.
Methods
NLR was calculated for 75 consecutive patients at presentation with HCC and regression models were used to analyze its value for predicting treatment strategy and short‐term survival with Child‐Pugh and Model for End Stage Liver Disease (MELD).
Results
NLR was not predictive of future treatment regimens with hepatectomy, liver transplant, or transarterial chemoembolization (TACE; odds ratio [OR]: 0.85, 95% confidence interval [CI]: 0.71–1.02, P = 0.079) as compared the predictive value of MELD (OR: 0.81, CI: 0.72–0.93, P = 0.002) or Child‐Pugh (OR: 0.48, CI: 0.34–0.69, P < 0.001). Adding additional adjustment for treatment, NLR did not correlate with short‐term overall survival (hazard ratio [HR]: 1.09, CI: 0.95–1.24, P = 0.227). MELD also did not correlate with overall survival (HR: 1.04, CI: 0.96–1.13, P = 0.357) whereas Child‐Pugh (HR: 1.56, CI: 1.10–2.19, P = 0.011) was predictive.
Conclusions
This study does not support the prognostic value of NLR to guide therapy for HCC in a Western center, whereas MELD and Child‐Pugh score were more predictive. J. Surg. Oncol. 2014 109:95–97. © 2013 Wiley Periodicals, Inc. |
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Bibliography: | ArticleID:JSO23448 istex:A397DAE9806ADBFFBE3B1C729FA36DF01295C69C ark:/67375/WNG-6M2BFSV9-1 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-4790 1096-9098 |
DOI: | 10.1002/jso.23448 |