Haemophilia A (factor VIII deficiency) in a litter of Weimaraners

• Published in: Journal of small animal practice Vol. 50; no. 7; pp. 357 - 359
• Main Authors: Dunning, M.D, Averis, G.F, Pattinson, H, Targett, M, Cade, S, Herrtage, M.E
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.07.2009; Blackwell Publishing Ltd
• Subjects: Animals; blood coagulation factors; dog breeds; dog diseases; Dog Diseases - genetics; Dogs; factor VIII; Factor VIII - genetics; genetic disorders; Genetic Predisposition to Disease; hemophilia; Hemophilia A - genetics; Hemophilia A - veterinary; inheritance (genetics); litters (young animals); Male; males; Mutation; Pedigree; puppies; screening; stochastic mutation; Weimaraner (dog breed)
• ISSN: 0022-4510; 1748-5827
• DOI: 10.1111/j.1748-5827.2009.00727.x

Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often results from a de novo stochastic mutation. We found no evidence using currently available screening tests of haemophilia A in relatives as far back as three generations making a stochastic mutation possible in this litter.