Amygdala activation during reading of emotional adjectives-an advantage for pleasant content

• Published in: Social cognitive and affective neuroscience Vol. 4; no. 1; pp. 35 - 49
• Main Authors: Herbert, Cornelia, Ethofer, Thomas, Anders, Silke, Junghofer, Markus, Wildgruber, Dirk, Grodd, Wolfgang, Kissler, Johanna
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2009
• Subjects: Adult; Amygdala - physiology; Arousal - physiology; Brain - physiology; Cerebral Cortex - physiology; Emotions - physiology; Female; Functional Laterality - physiology; Humans; Image Processing, Computer-Assisted; Limbic System - physiology; Magnetic Resonance Imaging; Male; Memory - physiology; Mental Recall - physiology; Original; Photic Stimulation; Psycholinguistics; Psychomotor Performance - physiology; Reading; Visual Cortex - physiology; amygdala; emotion; re-entrant processing; reading; extrastriate cortex; perception; neuroimaging
• ISSN: 1749-5016; 1749-5024
• DOI: 10.1093/scan/nsn027

This event-related functional magnetic resonance imaging (fMRI) study investigated brain activity elicited by emotional adjectives during silent reading without specific processing instructions. Fifteen healthy volunteers were asked to read a set of randomly presented high-arousing emotional (pleasant and unpleasant) and low-arousing neutral adjectives. Silent reading of emotional in contrast to neutral adjectives evoked enhanced activations in visual, limbic and prefrontal brain regions. In particular, reading pleasant adjectives produced a more robust activation pattern in the left amygdala and the left extrastriate visual cortex than did reading unpleasant or neutral adjectives. Moreover, extrastriate visual cortex and amygdala activity were significantly correlated during reading of pleasant adjectives. Furthermore, pleasant adjectives were better remembered than unpleasant and neutral adjectives in a surprise free recall test conducted after scanning. Thus, visual processing was biased towards pleasant words and involved the amygdala, underscoring recent theoretical views of a general role of the human amygdala in relevance detection for both pleasant and unpleasant stimuli. Results indicate preferential processing of pleasant information in healthy young adults and can be accounted for within the framework of appraisal theory.