Unani Formulation Habb-e-Suranjan: A Treasure of Biological Activities

• Published in: BioMed research international Vol. 2022; pp. 1640193 - 11
• Main Authors: Ahemad, Ansari Imtiyaz Ahmed Tufail, Aejazuddin, Qazi Majaz Ahamad, Khan, G. J., Alsayari, Abdulrhman, Wahab, Shadma, Khan, Sharuk L., Akter, Noor Jahan, Islam, Md. Rezaul, Roy, Arpita, Islam, Fahadul
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2022; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acids; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - therapeutic use; Anti-inflammatory drugs; Arthralgia; Arthritis; Ascorbic acid; Carrageenan; Carrageenan - adverse effects; Catechin; Cell migration; Chemotaxis; Drug withdrawal; Edema; Edema - chemically induced; Edema - drug therapy; Gout; Health aspects; Herbal medicine; Hippocrates (460?-377? BC); Hydroxyl radicals; Identification and classification; In vivo methods and tests; Incubation; Inflammation; Inflammation - drug therapy; Lifestyles; Medicine; Medicine, Oriental; Nitric Oxide; Nonsteroidal anti-inflammatory drugs; Pain; Pharmacology, Experimental; Phytochemicals; Plant Extracts - therapeutic use; Rats; Rheumatism; Scavenging; Sodium; Sodium nitroprusside; Thickness; India; United States > US
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2022/1640193

Habb-e-Suranjan (HES), an Unani formulation, has been studied for its anti-inflammatory properties in both in vitro and in vivo experiments. HES is recommended for arthritis, gout, and joint pain. The current endeavor is an attempt to put it to the test and verify its efficacy scientifically. It was tested for DPPH, hydroxyl, and nitric oxide scavenging activities. It was shown that HES had the greatest TAC and FRAC values when compared to catechin and ascorbic acid. HES exhibited DPPH and hydroxyl radical scavenging activity that was dose-dependent. Incubation of sodium nitroprusside solutions in PBS at 25°C for 150 min resulted in the production of nitric oxide. Nitric oxide production was effectively decreased by HES. Anti-inflammatory medications boosted the migration of PMN cells toward the chemoattractant FMLP in an agarose experiment of PMN chemotaxis. In carrageenan-induced rat paw edema, in the HES-treated group, paw thickness was 3.021±0.084 at t=0, but it showed an increase in paw inflammation after one hour, i.e., 3.195±0.082 cm which again showed a decrease in paw thickness up to 4th hour, i.e., 3.018±0.078, 2.98±0.032, and 2.684±0.061 at t=2, 3, and 4, respectively. It showed again getting back to the normal thickness of paw at t=24 hrs, i.e., 3.029±0.118 cm. It is concluded that the formulation is potent enough and can be used effectively for the treatment of inflammation and associated health issues. Moreover, there is much scope to evaluate its effectiveness using different in vitro and in vivo models.