Association of Hyperinsulinemia and Serum Free Fatty Acids with Serum High Density Lipoprotein-Cholesterol

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 2; no. 1; pp. 53 - 59
• Main Authors: Hashimoto, Ryuichi, Adachi, Hisashi, Tsuruta, Makoto, Tashiro, Hiromi, Toshima, Hironori
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 1995
• Subjects: Adult; Coronary Disease - etiology; Fatty Acids - blood; Female; FFA; Humans; Hyperinsulinism; Insulin Resistance; Lipoproteins, HDL - blood; Male; Middle Aged; Obesity; Risk factor; Risk Factors
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat1994.2.53

A total of 155 Japanese subjects (79 men and 76 women) who were classified as having normal or borderline glucose tolerance, according to the criteria for the 50-g oral glucose tolerance test (GTT) of the Japanese Diabetes Society, were analyzed for factors related to serum high density lipoprotein (HDL) -cholesterol concentration, especially the responses of insulin and free fatty acid (FFA) after a glucose challenge. In men, significant negative univariate correlations were observed with body mass index (P<0.01), the summed values of triceps and subscapular skin-folds (P<0.01), serum insulin concentration at all time intervals, and serum FFA at 30 and 60 min of GTT. Serum insulin at 60, 120, and 180 min, sum insulin, and FFA at 30 and 60 min of GTT were significantly related to serum HDL-cholesterol after adjustment for body mass index and triglyceride concentration. Multiple linear regression analysis with the step-forward method showed that sum insulin (P<0.01), FFA at 60 min of GTT (P<0.001), and alcohol consumption (P<0.01) were independently related to serum HDL-cholesterol concentration. Only the triglyceride concentration was inversely correlated (P<0.05) with HDL-cholesterol concentration in women. These data indicate that both insulin and FFA concentrations, as markers of insulin resistance, apparently influence on HDL kinetics in men, but not in women. The lack of this association in women was appeared to related to the degree of obesity. J Atheroscler Thromb, 1995 ; 2 : 53-59.