NOVEL MICROBIAL METABOLITES OF THE PHOSLACTOMYCINS FAMILY INDUCE PRODUCTION OF COLONY-STIMULATING FACTORS BY BONE MARROW STROMAL CELLS II. ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

• Published in: Journal of antibiotics Vol. 46; no. 10; pp. 1512 - 1519
• Main Authors: KOHAMA, TAKAFUMI, NAKAMURA, TAKEMICHI, KINOSHITA, TAKESHI, KANEKO, ISAO, SHIRAISHI, AKIO
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1993; Japan Antibiotics Research Association
• Subjects: Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Bone Marrow - drug effects; Chromatography, High Pressure Liquid; Granulocyte Colony-Stimulating Factor - biosynthesis; Lactones - chemistry; Lactones - isolation & purification; Lactones - pharmacology; Medical sciences; Organophosphorus Compounds - chemistry; Organophosphorus Compounds - isolation & purification; Organophosphorus Compounds - pharmacology; Pharmacology. Drug treatments; Pyrones; Streptomyces - chemistry; Streptomyces platensis; Streptomycetaceae; Secretion; Cytokine; Colony stimulating factor; Inductor; Actinomycetales; Microbial origin; Hematopoiesis; Bacteria; Isolation; Actinomycetes; Physicochemical properties; Streptomyces platensis; Structural analysis; Growth factor

Leustroducsins (LSNs) A, B and C, novel inducers of colony-stimulating factors (CSFs), were isolated from culture broth of Streptomyces platensis SANK 60191 mainly by ethyl acetate extraction and preparative reverse-phase HPLC. The molecular weights and molecular formulae of LSNs A, B and C are 641:...