NOVEL MICROBIAL METABOLITES OF THE PHOSLACTOMYCINS FAMILY INDUCE PRODUCTION OF COLONY-STIMULATING FACTORS BY BONE MARROW STROMAL CELLS II. ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

Leustroducsins (LSNs) A, B and C, novel inducers of colony-stimulating factors (CSFs), were isolated from culture broth of Streptomyces platensis SANK 60191 mainly by ethyl acetate extraction and preparative reverse-phase HPLC. The molecular weights and molecular formulae of LSNs A, B and C are 641:...

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Bibliographic Details
Published inJournal of antibiotics Vol. 46; no. 10; pp. 1512 - 1519
Main Authors KOHAMA, TAKAFUMI, NAKAMURA, TAKEMICHI, KINOSHITA, TAKESHI, KANEKO, ISAO, SHIRAISHI, AKIO
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1993
Japan Antibiotics Research Association
Subjects
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Bone Marrow - drug effects
Chromatography, High Pressure Liquid
Granulocyte Colony-Stimulating Factor - biosynthesis
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Medical sciences
Organophosphorus Compounds - chemistry
Organophosphorus Compounds - isolation & purification
Organophosphorus Compounds - pharmacology
Pharmacology. Drug treatments
Pyrones
Streptomyces - chemistry
Streptomyces platensis
Streptomycetaceae
Secretion
Cytokine
Colony stimulating factor
Inductor
Actinomycetales
Microbial origin
Hematopoiesis
Bacteria
Isolation
Actinomycetes
Physicochemical properties
Streptomyces platensis
Structural analysis
Growth factor
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Summary:Leustroducsins (LSNs) A, B and C, novel inducers of colony-stimulating factors (CSFs), were isolated from culture broth of Streptomyces platensis SANK 60191 mainly by ethyl acetate extraction and preparative reverse-phase HPLC. The molecular weights and molecular formulae of LSNs A, B and C are 641: C32H52O10NP, 669: C34H56O10NP and 669: C34H56O10NP, respectively. The structure elucidation revealed that they belong to the phoslactomycin group antibiotics, and their structures contain an α, β-unsaturated δ-lactone, an amino group, a phosphate ester and a cyclohexane ring moiety. The structures differ only at the substituent bound to the cyclohexane ring.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1512