Enantioselective Chemo‐ and Biocatalysis: Partners in Retrosynthesis

• Published in: Angewandte Chemie International Edition Vol. 56; no. 31; pp. 8942 - 8973
• Main Authors: Hönig, Moritz, Sondermann, Philipp, Turner, Nicholas J., Carreira, Erick M.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 24.07.2017
• Edition: International ed. in English
• Subjects: Acylation; Alcohols - chemical synthesis; Alcohols - chemistry; Alcohols - metabolism; Amination; Amines - chemical synthesis; Amines - chemistry; Amines - metabolism; Biocatalysis; Catalysis; Chemical synthesis; Enantiomers; enantioselectivity; Enzymes - metabolism; Hydrolysis; Organic Chemicals - chemical synthesis; Organic Chemicals - chemistry; Organic Chemicals - metabolism; Oxidation-Reduction; retrosynthesis; Stereoisomerism; enantioselectivity; catalysis; biocatalysis; retrosynthesis
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201612462

Recent developments of stereoselective biocatalytic and chemocatalytic methods are discussed. The review provides a guide to the use of biocatalytic methods in the area of chemical synthesis with focused attention on retrosynthetic considerations and analysis. The transformations presented are organized according to bond disconnections and attendant synthetic methods. The review is expected to lead to better understanding of the characteristics and distinctions of the two complementary approaches. It depicts for researchers in bio‐ and chemocatalysis a road map of challenges and opportunities for the evolution (and at times revolution) in chemical synthesis. Partners in synthesis: This Review provides a guide to the use of biocatalytic methods in the area of chemical synthesis with focus on retrosynthetic considerations and analysis. It is expected to lead to better understanding of the characteristics and distinctions of the two complementary approaches by depicting a road map of challenges and opportunities for the evolution in chemical synthesis.