Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia

• Published in: Schizophrenia research Vol. 80; no. 2-3; pp. 197 - 201
• Main Authors: Kirihara, Kenji, Araki, Tsuyoshi, Kasai, Kiyoto, Maeda, Keiko, Hata, Akinobu, Uetsuki, Miki, Yamasue, Hidenori, Rogers, Mark A., Kato, Nobumasa, Iwanami, Akira
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.12.2005; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Event-related potentials; Event-Related Potentials, P300 - physiology; Female; Humans; Male; Medical sciences; P300; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - complications; Schizophrenia - physiopathology; Severity of Illness Index; Thinking; Thought disorder; Schizophrenia; Thought disorder; Event-related potentials; P300; Human; Central nervous system; Electrophysiology; P300 potential; Encephalon; Psychosis; Hearing; Perception; Event evoked potential
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/j.schres.2005.08.003

We have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia.