Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: possible role of nuclear factor kappa B

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 65; no. 9; p. 941
• Main Authors: Arranz, Lorena, Caamaño, Jorge H, Lord, Janet M, De la Fuente, Mónica
• Format: Journal Article
• Language: English
• Published: United States 01.09.2010
• Subjects: Aging - metabolism; Animals; Catalase - metabolism; Cell Proliferation; Cross-Sectional Studies; Female; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Interleukin-2 - metabolism; Leukocytes - metabolism; Longevity; Macrophages, Peritoneal - physiology; Mice; Mice, Inbred ICR; NF-kappa B - metabolism; Oxidative Stress - immunology; Peritoneum - cytology; Phagocytosis; Reactive Oxygen Species; Xanthine Oxidase - metabolism

In order to verify the survival biomarker role of several immune functions, and to determine the oxidation and inflammation mechanisms underlying variability in the aging process, we have investigated a variety of immune functions and oxidative stress parameters as well as activation of the nuclear...