Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: possible role of nuclear factor kappa B

In order to verify the survival biomarker role of several immune functions, and to determine the oxidation and inflammation mechanisms underlying variability in the aging process, we have investigated a variety of immune functions and oxidative stress parameters as well as activation of the nuclear...

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Published inThe journals of gerontology. Series A, Biological sciences and medical sciences Vol. 65; no. 9; p. 941
Main Authors Arranz, Lorena, Caamaño, Jorge H, Lord, Janet M, De la Fuente, Mónica
Format Journal Article
LanguageEnglish
Published United States 01.09.2010
Subjects
Aging - metabolism
Animals
Catalase - metabolism
Cell Proliferation
Cross-Sectional Studies
Female
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Interleukin-2 - metabolism
Leukocytes - metabolism
Longevity
Macrophages, Peritoneal - physiology
Mice
Mice, Inbred ICR
NF-kappa B - metabolism
Oxidative Stress - immunology
Peritoneum - cytology
Phagocytosis
Reactive Oxygen Species
Xanthine Oxidase - metabolism
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Summary:In order to verify the survival biomarker role of several immune functions, and to determine the oxidation and inflammation mechanisms underlying variability in the aging process, we have investigated a variety of immune functions and oxidative stress parameters as well as activation of the nuclear factor kappa B (NF kappaB) in peritoneal leukocytes from four different age groups of mice, including natural extreme longevity. Immune cells from naturally long-lived animals showed preservation of immune function in response to stimuli and controlled oxidative stress as well as nuclear factor kappa B activation in resting conditions. Moreover, leukocytes from extreme long-lived animals showed increased catalase activity when compared with the adults. In contrast, the old and very old animal groups showed impaired immune function and increased oxidation as well as NF kappaB activation. Our results support preserved immune function as a biomarker of extended survival and point to controlled regulation of NF kappaB activity as a key mechanism restraining oxidative stress in immune cells and contributing to reach longevity.
ISSN:1758-535X
DOI:10.1093/gerona/glq101