Pathological Femoral Fracture due to Osteoporosis and Hypophosphatemic Osteomalacia Following Adefovir Therapy in a Patient with Chronic Hepatitis B

Adefovir dipivoxil (ADV) is a nucleotide analogue used in the chronic hepatitis B treatment. Proximal renal tubular dysfunction is one of the adverse effects of this agent and characterized with hypophosphatemia and osteomalacia. However, reduced bone mineral density with fracture due to ADV therapy...

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Bibliographic Details
Published inTurkish journal of osteoporosis Vol. 24; no. 2; pp. 59 - 62
Main Authors Batıbay, Sevilay, Geler Külcü, Duygu, Mesci, Nilgün, Ruhi, Borçak Çağlar, Şahin, Zerrin, Gündoğdu, Hasan
Format Journal Article
LanguageEnglish
Turkish
Published Istanbul Türkiye Osteoporoz Derneği 01.08.2018
Galenos Publishing House
Galenos Yayinevi
Subjects
Adefovir dipivoxil
Antiviral drugs
Bone marrow
Drug dosages
fracture
Fractures
Hepatitis
Hepatitis B
Hepatology
hypophosphatemia
Infections
Interferon
Literature reviews
Mitochondrial DNA
NMR
Nuclear magnetic resonance
osteomalacia
Osteoporosis
Pain
Tıp
Tumor necrosis factor-TNF
Vertebrae
Vitamin D
İstanbul
Türkiye
osteomalacia
Adefovir dipivoksil
kırık
Adefovir dipivoxil
osteoporoz
osteoporosis
hypophosphatemia
hipofosfatemi
fracture
osteomalazi
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Summary:Adefovir dipivoxil (ADV) is a nucleotide analogue used in the chronic hepatitis B treatment. Proximal renal tubular dysfunction is one of the adverse effects of this agent and characterized with hypophosphatemia and osteomalacia. However, reduced bone mineral density with fracture due to ADV therapy has not been reported before. We aimed to report a 55-year-old male patient with proximal femur fracture who developed hypophosphatemic osteomalacia while using low dose of adefovir (10 mg/day) for chronic hepatitis B treatment for 10 years.
ISSN:2146-3816
2147-2653
2147-2653
DOI:10.4274/tod.04796