Equipment for drug release testing of medicated chewing gums

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 22; no. 3; pp. 405 - 411
• Main Authors: Kvist, L.Catharina, Andersson, Sven-Börje, Berglund, Johan, Wennergren, Bo, Fors, Susan M
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2000; Elsevier Science
• Subjects: Analysis; Antiemetics - administration & dosage; Antiemetics - analysis; Biological and medical sciences; Chemistry Techniques, Analytical - instrumentation; Chemistry, Pharmaceutical; Chewing Gum; Chromatography, High Pressure Liquid - methods; Dimenhydrinate; Dimenhydrinate - administration & dosage; Dimenhydrinate - analysis; Dosage Forms; Drug release testing in vitro; Equipment Design; Equipment for gum formulations; General pharmacology; Meclizine; Meclizine - administration & dosage; Meclizine - analysis; Medical sciences; Medicated gums; Nicotine; Nicotine - administration & dosage; Nicotine - analysis; Nicotinic Agonists - administration & dosage; Nicotinic Agonists - analysis; Pharmacology. Drug treatments; Xylitol; Xylitol - administration & dosage; Xylitol - analysis; Equipment for gum formulations; Xylitol; Drug release testing in vitro; Dimenhydrinate; Medicated gums; Nicotine; Meclizine; Drug; Pharmaceutical technology; Oral administration; HPLC chromatography; In vitro; Chewing gum; Absorption; Analysis method; Formulation; Quality control; Distribution; Dosage form; Batch production; Pharmacokinetics; Release; Quantitative analysis
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/S0731-7085(99)00307-6

An apparatus was specially designed and constructed for release testing of medicated chewing gums. The adjustable instrumental settings such as temperature, chewing frequency, chewing time, volume of test medium, distance between the jaws and twisting angle increased the versatility of the apparatus. Selection of the test medium was also an important parameter. Each sample was kneaded mechanically in separate test chambers and the drug release was followed by sampling and HPLC analysis. Different gum formulations were tested and the obtained results demonstrated satisfactory release curves for a variety of formulations and active ingredients. The tested gum formulations comprised nicotine, meclizine, dimenhydrinate and xylitol. The apparatus proved to be suitable in product control of commercial batches but also a useful tool in the research and development of medicated gum formulations.