Andrographolide – A prospective remedy for chikungunya fever and viral arthritis

• Published in: International immunopharmacology Vol. 99; p. 108045
• Main Authors: Gupta, Swati, Mishra, KP, Gupta, Rupali, Singh, SB
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2021; Elsevier BV
• Subjects: Andrographolide; Animals; Antiviral; Antiviral activity; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Apoptosis; Arthralgia; Arthritis; Arthritis, Infectious - drug therapy; Arthritis, Infectious - virology; Bioactive compounds; Chemical compounds; Chikungunya Fever - drug therapy; Chikungunya Fever - transmission; Chikungunya Fever - virology; Chikungunya virus; Chikungunya virus - drug effects; Complications; Diterpenes - pharmacology; Diterpenes - therapeutic use; Fever; Host Microbial Interactions; Humans; Immunology; Immunomodulation; Infections; Infectious diseases; Inflammation; Mitigation; Multiplication; Myalgia; Oxidative Stress; Pain; Protein folding; Proteins; Signs and symptoms; Unfolded Protein Response; Vector-borne diseases; Viral infections; Viruses; Oxidative Stress; ALT; Arthritis; FLS; CHIKF; HPV; IFN; AL-1; HIF1- α; OA; SARS-CoV-2; DENV; UPR; EBV; Antiviral; AIA; Andrographolide; IBV; HBV; AST; NOD; Mpro; Immunomodulation; SOD; Inflammation; p.i; Unfolded Protein Response; ER; PBMCs; RA; HIV; Chikungunya virus; CAT; HCV; NLRs; RLRs; CHIKV; TLRs; CFA; IAV; NOX2

[Display omitted] •Chikungunya is an arboviral disease caused by chikungunya virus (CHIKV) infection.•Till date no treatment is available for chikungunya.•Andrographolide (Andro) is a major bioactive compound of plant Andrographis paniculata.•Andro inhibits CHIKV multiplication and symptoms associat...