Human sperm associated antigen 4 (SPAG4) is a potential cancer marker

Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4. SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23. It is expressed in a limited number of normal ti...

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Published inCell and tissue research Vol. 315; no. 2; pp. 279 - 283
Main Authors Kennedy, Claire, Sebire, Kim, de Kretser, David M, O'Bryan, Moira K
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.02.2004
Subjects
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cloning, Molecular
Computational Biology
DNA, Complementary - genetics
Exons - genetics
Humans
Male
Neoplasms - genetics
Spermatozoa - metabolism
Tissue Distribution - genetics
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Summary:Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4. SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23. It is expressed in a limited number of normal tissues, notably the pancreas and testis, but is switched on and greatly upregulated in a wide range of neoplastic tissues. The data therefore strongly suggests that SPAG4 expression is a potential clinically relevant cancer marker.
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ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-003-0821-2