Low serum albumin level deteriorates prognosis in azacitidine-treated myelodysplastic syndromes patients - results of the PALG study 'PolAZA'

• Published in: Hematology (Luxembourg) Vol. 26; no. 1; pp. 556 - 564
• Main Authors: Mądry, Krzysztof, Lis, Karol, Tukiendorf, Andrzej, Szwedyk, Paweł, Kapelko-Słowik, Katarzyna, Subocz, Edyta, Gołos, Aleksandra, Makowska, Wioletta, Masternak, Anna, Kopińska, Anna, Czemerska, Magdalena, Zawadzka-Leska, Sara, Rusicka, Patrycja, Drozd-Sokołowska, Joanna, Wiater, Elżbieta, Hołojda, Jadwiga, Pogłódek, Bartłomiej, Centkowski, Piotr, Waszczuk-Gajda, Anna, Machowicz, Rafał, Hałka, Janusz, Czerw, Tomasz, Basak, Grzegorz, Dwilewicz-Trojaczek, Jadwiga
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 01.01.2021
• Subjects: albumin; azacitidine; Myelodysplastic syndromes
• ISSN: 1607-8454; 1607-8454
• DOI: 10.1080/16078454.2021.1956182

Azacitidine (AZA) is the standard of care for higher-risk myelodysplastic syndrome (HR-MDS) patients ineligible for intensive therapy. Clinical outcome discrepancies reported in clinical trials and real-life settings stimulate the search for new prognostic factors. We retrospectively evaluated 315 MDS, 20-30% blast acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) patients treated with azacitidine in 12 centers cooperating within the Polish Adult Leukemia Group (PALG). The median number of AZA cycles was 7 (1-69) and 24% patients received fewer than 4 cycles (early failure, EF). Serum albumin level was an independent predictor of EF occurrence. Complete remission (CR) was obtained in 20% and partial remission (PR) in 12% of patients. Hematologic improvement - erythroid (HI-E), neutrophil (HI-N), or platelet (HI-P) was achieved in 51%, 36%, and 48% of patients, respectively. No factors significantly predicted CR or PR in the multivariate analysis. For HI-E and HI-P, lower LDH level predicted response. Median survival was 15 (13-19) months. Lower serum albumin level, serious infection and receiving <4 AZA cycles independently predicted a worse overall survival (OS) (p < 0.05). Serum albumin assessment before azacitidine treatment can help to identify patients with higher risk of early failure and worse clinical outcome.