Changes in body composition in women treated with gonadotropin-releasing hormone agonists
Objective: The changes that agonists of gonadotropin-releasing hormone (GnRH) produce in mineral bone mass are known, but, as far as we know, those produced by these agents in other body compartments are unknown. Methods: We studied these changes using dual-energy X-ray absorptiometry in 50 eugonada...
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Published in | Maturitas Vol. 31; no. 1; pp. 63 - 68 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
30.11.1998
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: The changes that agonists of gonadotropin-releasing hormone (GnRH) produce in mineral bone mass are known, but, as far as we know, those produced by these agents in other body compartments are unknown.
Methods: We studied these changes using dual-energy X-ray absorptiometry in 50 eugonadal women treated with decapeptyl (Triptoreline®), 3.75 mg injected intramuscularly, at 28-day intervals for 6 months.
Results: There were significant increases in fat content (9.5%,
P<0.0005) and weight (1.3%,
P<0.01), and significant decreases in fat-free mass (−1.9%,
P<0.0001) and water content (−1.8%,
P<0.0002). Bone mass was lost in the axial skeleton (−3.6%,
P<0.0001) but not in the peripheral skeleton.
Conclusions: The changes induced in body composition by the GnRH agonists are similar to those of natural menopause. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0378-5122 1873-4111 |
DOI: | 10.1016/S0378-5122(98)00080-2 |