Cytotoxic activity of lignans from Hibiscus cannabinus

• Published in: Fitoterapia Vol. 78; no. 5; pp. 385 - 387
• Main Authors: Moujir, Laila, Seca, Ana M.L., Silva, Artur M.S., López, Manuel R., Padilla, Nayely, Cavaleiro, José A.S., Neto, Carlos P.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.2007; Elsevier
• Subjects: Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antimicrobial activity; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Biological and medical sciences; Cell Division - drug effects; Cell Line, Tumor - drug effects; Cytotoxic activity; General pharmacology; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Hibiscus; Hibiscus cannabinus; Humans; Lignans; Lignans - administration & dosage; Lignans - pharmacology; Lignans - therapeutic use; Medical sciences; Microbial Sensitivity Tests; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Bark; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Antimicrobial activity; Hibiscus cannabinus; Lignans; Cytotoxic activity; Malvaceae; Pharmacognosy; Cytotoxicity; Fiber crop; Antimicrobial agent; Medicinal plant; Dicotyledones; Angiospermae; Plant origin; Lignan; Spermatophyta
• ISSN: 0367-326X
• DOI: 10.1016/j.fitote.2007.03.010

The antimicrobial and cytotoxic activities of six lignans isolated from the core and bark acetone extracts of Hibiscus cannabinus have been investigated. Two compounds ( 2 and 3) showed strong cytotoxic activity against HeLa, Hep-2 and A-549 cell lines while compound 5 showed moderate activity on HeLa cells when they were in advanced stage of cellular division. The compounds did not exhibit antimicrobial activity.