Dual-wavelength laser speckle imaging to simultaneously access blood flow, blood volume, and oxygenation using a color CCD camera

We developed a dual-wavelength laser speckle imaging system using a single industrial-grade color CCD camera with Bayer filters to simultaneously image changes in blood flow, blood volume, and oxygenation. One frame of a color image recorded with dual-wavelength laser illumination provides not only...

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Bibliographic Details
Published inOptics letters Vol. 38; no. 18; p. 3690
Main Authors Wang, Jia, Wang, Yaru, Li, Bing, Feng, Danqi, Lu, Jinling, Luo, Qingming, Li, Pengcheng
Format Journal Article
LanguageEnglish
Published United States 15.09.2013
Subjects
Blood Circulation
Blood Volume
Color
Fingers - blood supply
Humans
Optical Imaging - instrumentation
Oxygen - metabolism
Time Factors
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Summary:We developed a dual-wavelength laser speckle imaging system using a single industrial-grade color CCD camera with Bayer filters to simultaneously image changes in blood flow, blood volume, and oxygenation. One frame of a color image recorded with dual-wavelength laser illumination provides not only the intensity fluctuation of the speckle pattern, but also the dual-wavelength optical reflectance signal. The method was validated using a tissue phantom and cuff ischemia experiments in the human arm. This system achieves complete time synchronization, unlike conventional time-sharing systems. Compared with a multicamera system, it also avoids the problem of image registration and can be less expensive.
ISSN:1539-4794
DOI:10.1364/ol.38.003690