Molecular and cellular effects of cardiac mechanotransduction during cardiopulmonary resuscitation and postresuscitation period: another piece in the puzzle

[...]the retrograde and antegrade coronary blood flow during CPR may induce a proinflammatory, prothrombotic state characterized by high cell turnover (resulting in both proliferation and death) relative to cells in static state [5]. [...]although our research in CPR is currently focused on oxidant...

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Published inThe American journal of emergency medicine Vol. 31; no. 1; pp. 250 - 252
Main Authors Chalkias, Athanasios, PhD, Johnson, Elizabeth O., PhD, Xanthos, Theodoros, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 2013
Elsevier Limited
Subjects
Cardiopulmonary Resuscitation
Cell Survival
CPR
Emergency
Emergency medical care
Gene expression
Heart
Heart Arrest - physiopathology
Heart Arrest - therapy
Humans
Inflammation - physiopathology
Ischemia
Mechanotransduction, Cellular - physiology
Oxidative Stress - physiology
Proteins
Reperfusion Injury - physiopathology
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Summary:[...]the retrograde and antegrade coronary blood flow during CPR may induce a proinflammatory, prothrombotic state characterized by high cell turnover (resulting in both proliferation and death) relative to cells in static state [5]. [...]although our research in CPR is currently focused on oxidant stress, inflammation, and ischemia-reperfusion injury, specific attention should be given to the complex area of mechanotransduction and mechanical signaling because there is evidence that it is equally important.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2012.08.010