Mode of action of angiotensin II and vasopressin on their target cells

In this short review, the cellular mode of action of angiotensin II and arginine-vasopressin is described with emphasis on the transmembrane signalling system. Two target cells are considered: the zona glomerulosa cell of the adrenal gland and the vascular smooth muscle cell. The information provide...

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Bibliographic Details
Published inHormone research Vol. 34; no. 3-4; p. 105
Main Authors Vallotton, M B, Capponi, A M, Johnson, E I, Lang, U
Format Journal Article
LanguageEnglish
Published Switzerland 1990
Subjects
Angiotensin II - physiology
Animals
Calcium - metabolism
Diglycerides - physiology
Glomerular Mesangium - physiology
Humans
Hydrogen - physiology
Inositol 1,4,5-Trisphosphate - physiology
Muscle, Smooth, Vascular - physiology
Protein Kinase C - physiology
Receptors, Angiotensin - physiology
Signal Transduction - physiology
Sodium - physiology
Vasopressins - physiology
Zona Glomerulosa - physiology
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Summary:In this short review, the cellular mode of action of angiotensin II and arginine-vasopressin is described with emphasis on the transmembrane signalling system. Two target cells are considered: the zona glomerulosa cell of the adrenal gland and the vascular smooth muscle cell. The information provided should help practitioners in endocrinology and hypertension to understand the physiological concepts which are expected to form the basis for future therapeutic developments.
ISSN:0301-0163
DOI:10.1159/000181806