New biodegradable polymers for injectable drug delivery systems
Many biodegradable polymers were used for drug delivery and some are successful for human application. There remains fabrication problems, such as difficult processability and limited organic solvent and irreproducible drug release kinetics. New star-shaped block copolymers, of which the typical mol...
Saved in:
Published in | Journal of controlled release Vol. 62; no. 1-2; pp. 109 - 114 |
---|---|
Main Authors | , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Amsterdam
Elsevier B.V
01.11.1999
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Many biodegradable polymers were used for drug delivery and some are successful for human application. There remains fabrication problems, such as difficult processability and limited organic solvent and irreproducible drug release kinetics. New star-shaped block copolymers, of which the typical molecular architecture is presented, results from their distinct solution properties, thermal properties and morphology. Their unique physical properties are due to the three-dimensional, hyperbranched molecular architecture and influence microsphere fabrication, drug release and degradation profiles. We recently synthesized thermosensitive biodegradable hydrogel consisting of polyethylene oxide and poly(l-lactic acid). Aqueous solution of these copolymers with proper combination of molecular weights exhibit temperature-dependent reversible sol-gel transition. Desired molecular arrangements provide unique behavior that sol (at low temperature) form gel (at body temperature). The use of these two biodegradable polymers have great advantages for sustained injectable drug delivery systems. The formulation is simple, which is totally free of organic solvent. In sol or aqueous solution state of this polymer solubilized hydrophobic drugs prior to form gel matrix. |
---|---|
AbstractList | Many biodegradable polymers were used for drug delivery and some are successful for human application. There remains fabrication problems, such as difficult processability and limited organic solvent and irreproducible drug release kinetics. New star-shaped block copolymers, of which the typical molecular architecture is presented, results from their distinct solution properties, thermal properties and morphology. Their unique physical properties are due to the three-dimensional, hyperbranched molecular architecture and influence microsphere fabrication, drug release and degradation profiles. We recently synthesized thermosensitive biodegradable hydrogel consisting of polyethylene oxide and poly(L-lactic acid). Aqueous solution of these copolymers with proper combination of molecular weights exhibit temperature-dependent reversible sol-gel transition. Desired molecular arrangements provide unique behavior that sol (at low temperature) form gel (at body temperature). The use of these two biodegradable polymers have great advantages for sustained injectable drug delivery systems. The formulation is simple, which is totally free of organic solvent. In sol or aqueous solution state of this polymer solubilized hydrophobic drugs prior to form gel matrix. |
Author | Bae, Y.H. Kim, S.W. Jeong, B. Choi, Y.K. Zentner, G. |
Author_xml | – sequence: 1 givenname: B. surname: Jeong fullname: Jeong, B. organization: Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA – sequence: 2 givenname: Y.K. surname: Choi fullname: Choi, Y.K. organization: Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA – sequence: 3 givenname: Y.H. surname: Bae fullname: Bae, Y.H. organization: Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA – sequence: 4 givenname: G. surname: Zentner fullname: Zentner, G. organization: MacroMed, Inc., 419 Wakara Way, Suite 205, Salt Lake City, UT 84108, USA – sequence: 5 givenname: S.W. surname: Kim fullname: Kim, S.W. organization: Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, University of Utah, Salt Lake City, UT 84112, USA |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1180603$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10518642$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkE1LAzEQhoMo9kN_grIHD3pYTbqbZHMqUvyCogf1HLLJpKTsR0nayv57025Rb15mYHjeYeYZoeOmbQChC4JvCSbs7j2WIs0YFddC3GCMGUnFERqSgmdpLgQ9RsMfZIBGISwjRLOcn6IBwZQULJ8M0fQVvpLStQYWXhlVVpCs2qqrwYfEtj5xzRL0ej83frNIDFRuC75LQhfWUIczdGJVFeD80Mfo8_HhY_aczt-eXmb381RnAq9TYDS3FiuiOLFZbktjqACjGC45BTbhE1poynKuudBGCc0x1cpqxZkpCqyzMaL9Xu3bEDxYufKuVr6TBMudELkXInffSiHkXogUMXfZ51absgbzJ9UbiMDVAVBBq8p61WgXfjlSYIaziE17DOKTWwdeBu2g0WCcj4Kkad0_l3wDeqt_eg |
CODEN | JCREEC |
CitedBy_id | crossref_primary_10_1016_j_ijpharm_2017_09_042 crossref_primary_10_1016_j_colsurfa_2004_04_070 crossref_primary_10_1002_jbm_a_35253 crossref_primary_10_1021_ma0100450 crossref_primary_10_1016_j_drudis_2013_01_013 crossref_primary_10_1016_j_polymer_2007_12_034 crossref_primary_10_1016_j_jconrel_2012_04_010 crossref_primary_10_1016_j_actbio_2012_03_006 crossref_primary_10_1007_BF03218672 crossref_primary_10_1016_j_progpolymsci_2011_06_004 crossref_primary_10_1177_0883911505049652 crossref_primary_10_1016_j_eurpolymj_2016_12_035 crossref_primary_10_3923_pjbs_2006_2145_2148 crossref_primary_10_1007_s00289_012_0747_5 crossref_primary_10_1016_j_jconrel_2014_03_052 crossref_primary_10_1002_jbm_a_34275 crossref_primary_10_1016_j_reactfunctpolym_2012_10_003 crossref_primary_10_1016_j_snb_2016_04_136 crossref_primary_10_1146_annurev_matsci_36_032905_091005 crossref_primary_10_1002_pi_2886 crossref_primary_10_1002_1097_4636_2001_58_1_127__AID_JBM190_3_0_CO_2_G crossref_primary_10_1016_S0167_7799_02_01962_5 crossref_primary_10_1016_S1535_5535_04_00214_X crossref_primary_10_1002_pat_1170 crossref_primary_10_1016_j_carbpol_2013_01_008 crossref_primary_10_1128_AAC_02139_19 crossref_primary_10_1002_app_48678 crossref_primary_10_1007_s10965_010_9428_y crossref_primary_10_1517_17425247_5_10_1077 crossref_primary_10_1039_b926720d crossref_primary_10_1021_ma047895a crossref_primary_10_1038_sj_mt_6300156 crossref_primary_10_1002_admt_201900043 crossref_primary_10_1007_s10692_017_9784_z crossref_primary_10_1021_ma001852m crossref_primary_10_1016_j_jcis_2019_07_028 crossref_primary_10_1016_S0378_5173_03_00076_0 crossref_primary_10_1080_15685551_2016_1198882 crossref_primary_10_1039_c0sm00764a crossref_primary_10_1002_app_32364 crossref_primary_10_1016_j_actbio_2009_08_036 crossref_primary_10_1016_j_ijpharm_2003_11_010 crossref_primary_10_1016_S0168_3659_01_00547_8 crossref_primary_10_1016_j_jconrel_2009_04_012 crossref_primary_10_1016_S1359_0286_02_00077_3 crossref_primary_10_1016_j_biomaterials_2004_01_051 crossref_primary_10_1016_j_mtcomm_2021_102455 crossref_primary_10_1142_S2251237313300027 crossref_primary_10_1021_acs_biomac_9b01009 crossref_primary_10_1016_j_addr_2016_05_005 crossref_primary_10_1016_j_biomaterials_2010_04_009 crossref_primary_10_1002_macp_200500483 crossref_primary_10_1016_j_ijpharm_2007_01_018 crossref_primary_10_1016_S0168_3659_03_00199_8 crossref_primary_10_1002_masy_200950526 crossref_primary_10_1016_j_jfoodeng_2012_12_034 crossref_primary_10_1080_03602550802353136 crossref_primary_10_1016_j_addr_2021_01_006 crossref_primary_10_1007_s11095_007_9384_3 crossref_primary_10_1016_j_polymer_2015_04_036 crossref_primary_10_1002_adfm_201403992 crossref_primary_10_1016_j_eurpolymj_2021_110292 crossref_primary_10_1002_pola_10595 crossref_primary_10_1002_polb_23081 crossref_primary_10_1208_s12249_014_0198_4 crossref_primary_10_1016_j_colsurfb_2018_08_048 crossref_primary_10_1002_pi_6266 crossref_primary_10_1002_app_29740 crossref_primary_10_3923_ijp_2006_513_519 crossref_primary_10_1177_0883911507085070 crossref_primary_10_1007_s11595_010_0090_3 crossref_primary_10_1016_j_jconrel_2004_11_016 crossref_primary_10_1016_j_jcis_2006_07_085 crossref_primary_10_1021_bc049697u crossref_primary_10_1016_j_addr_2016_07_004 crossref_primary_10_1002_jbm_b_30858 crossref_primary_10_1016_j_progpolymsci_2008_07_005 crossref_primary_10_1021_bm010137x crossref_primary_10_1557_PROC_785_D8_3 crossref_primary_10_1002_mabi_200300037 crossref_primary_10_1021_bm2009558 crossref_primary_10_1002_pola_21480 crossref_primary_10_1016_S0169_409X_01_00203_4 crossref_primary_10_1016_j_ejpb_2004_03_003 crossref_primary_10_1016_j_jddst_2023_104885 crossref_primary_10_1007_s40005_019_00442_2 crossref_primary_10_1080_00914037_2019_1616198 crossref_primary_10_1080_15583724_2014_995806 crossref_primary_10_1021_ma021639l crossref_primary_10_1002_jbm_a_31396 crossref_primary_10_1002_jbm_a_31674 crossref_primary_10_1163_1568562041526496 crossref_primary_10_1021_ma061960u crossref_primary_10_1063_1_1610445 crossref_primary_10_1515_epoly_2019_0041 crossref_primary_10_1016_j_jevs_2012_11_003 crossref_primary_10_1080_15421406_2012_635530 crossref_primary_10_1016_j_cej_2020_126946 crossref_primary_10_1016_j_cis_2011_06_005 crossref_primary_10_1007_s10856_006_0617_5 crossref_primary_10_1016_j_biomaterials_2008_12_083 crossref_primary_10_1016_j_chemphyslip_2021_105101 crossref_primary_10_1016_j_ijpharm_2015_08_035 crossref_primary_10_1002_app_23469 crossref_primary_10_1016_S0168_3659_02_00008_1 crossref_primary_10_1016_j_cej_2024_152286 crossref_primary_10_3390_polym3020779 crossref_primary_10_1002_mabi_200600129 crossref_primary_10_1016_j_ijpharm_2014_06_029 crossref_primary_10_1080_17425247_2020_1789587 crossref_primary_10_1007_BF03218911 crossref_primary_10_3390_pharmaceutics14112331 crossref_primary_10_1016_j_ijbiomac_2015_01_046 crossref_primary_10_1021_cr000108x crossref_primary_10_3390_pharmaceutics14020359 crossref_primary_10_1016_j_addr_2012_09_012 crossref_primary_10_1177_0883911508095245 crossref_primary_10_1002_marc_201700410 crossref_primary_10_1016_j_carbpol_2011_09_089 crossref_primary_10_1021_bc049784m crossref_primary_10_1002_app_30397 crossref_primary_10_1016_j_biomaterials_2004_07_064 crossref_primary_10_1016_j_biomaterials_2015_10_022 crossref_primary_10_1021_ma012093q crossref_primary_10_1111_j_1872_034X_2009_00576_x crossref_primary_10_1177_0883911509356377 crossref_primary_10_1016_j_biomaterials_2006_05_038 crossref_primary_10_1039_b900198k crossref_primary_10_1021_nn900785b crossref_primary_10_1016_j_colsurfa_2007_03_006 crossref_primary_10_1163_156855511X598614 crossref_primary_10_1007_s12272_013_0013_x crossref_primary_10_1002_mabi_200400073 crossref_primary_10_1021_ma047742n crossref_primary_10_1016_j_ijpharm_2016_01_040 crossref_primary_10_1071_CH15094 crossref_primary_10_1016_j_ejpb_2008_10_018 crossref_primary_10_1016_j_jconrel_2014_03_026 crossref_primary_10_1016_S1748_0132_08_70043_4 crossref_primary_10_1163_156855508X298017 crossref_primary_10_1007_s12588_016_9156_1 crossref_primary_10_1016_j_addr_2012_09_024 crossref_primary_10_1016_S0958_1669_00_00202_0 crossref_primary_10_1021_ma035453d crossref_primary_10_1002_mabi_200500096 crossref_primary_10_1517_13543776_11_9_1395 crossref_primary_10_1016_j_electacta_2024_144472 crossref_primary_10_1016_j_polymer_2013_10_025 crossref_primary_10_1021_ma201261m crossref_primary_10_1016_j_ejpb_2008_09_021 crossref_primary_10_1177_0885328208100536 crossref_primary_10_1016_S0169_409X_01_00242_3 crossref_primary_10_1002_pola_23877 crossref_primary_10_1177_1074248406297326 crossref_primary_10_1007_BF03218454 crossref_primary_10_1002_mabi_200900402 crossref_primary_10_1163_1568562042459751 crossref_primary_10_1021_bm034190s crossref_primary_10_1002_pat_1555 crossref_primary_10_1002_jbm_1248 crossref_primary_10_1021_ct501152a crossref_primary_10_1088_0964_1726_16_3_043 crossref_primary_10_1016_j_ijpharm_2005_01_017 crossref_primary_10_3390_nano10101970 crossref_primary_10_1016_j_jconrel_2008_01_005 crossref_primary_10_1016_j_jfoodeng_2011_12_034 crossref_primary_10_3109_10837451003774369 crossref_primary_10_1002_pola_10201 crossref_primary_10_1016_j_actbio_2011_05_035 crossref_primary_10_1016_j_polymdegradstab_2008_12_013 crossref_primary_10_1007_s11051_015_2878_8 crossref_primary_10_1080_03639045_2017_1287718 crossref_primary_10_1080_10236661003746405 crossref_primary_10_1517_17425247_4_5_533 crossref_primary_10_1016_j_bios_2016_03_045 crossref_primary_10_1002_jps_23065 crossref_primary_10_1002_marc_200700564 crossref_primary_10_1039_C7PY00219J crossref_primary_10_2174_0929867325666180927100817 crossref_primary_10_1016_j_jconrel_2015_04_026 crossref_primary_10_1007_s11095_005_8417_z crossref_primary_10_1016_S0168_3659_02_00146_3 crossref_primary_10_1039_b902208b crossref_primary_10_1016_j_polymer_2005_04_024 crossref_primary_10_3390_pharmaceutics15020533 crossref_primary_10_1016_j_biomaterials_2004_11_002 crossref_primary_10_1016_j_progpolymsci_2007_04_001 crossref_primary_10_1016_j_ijpharm_2007_03_054 crossref_primary_10_1016_j_ijpharm_2014_07_032 crossref_primary_10_3390_ijms232314611 |
Cites_doi | 10.1126/science.8134835 10.1002/jps.2600791016 10.1016/0168-3659(91)90029-D 10.1016/0168-3659(90)90139-K 10.1002/jbm.820190806 10.1016/0169-409X(93)90046-7 10.1021/cen-v063n011.p022 10.1021/ma981069i 10.1073/pnas.90.9.4176 10.1016/0168-3659(93)90155-X 10.1002/macp.1997.021981105 10.1016/0168-3659(94)90159-7 10.1038/42218 10.1021/ja00177a074 10.1021/ma00046a049 10.1016/0168-3659(92)90021-I |
ContentType | Journal Article Conference Proceeding |
Copyright | 1999 Elsevier Science B.V. 2000 INIST-CNRS |
Copyright_xml | – notice: 1999 Elsevier Science B.V. – notice: 2000 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION |
DOI | 10.1016/S0168-3659(99)00061-9 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1873-4995 |
EndPage | 114 |
ExternalDocumentID | 10_1016_S0168_3659_99_00061_9 10518642 1180603 S0168365999000619 |
Genre | Research Support, U.S. Gov't, P.H.S Journal Article |
GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: GM56098 |
GroupedDBID | --- --K --M .~1 1B1 1RT 1~. 1~5 29K 3O- 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AABNK AABXZ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO AAYOK ABFNM ABFRF ABJNI ABMAC ABOCM ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACNNM ACRLP ADBBV ADEZE ADMUD AEFWE AEKER AENEX AEZYN AFKWA AFRZQ AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 D-I DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q HMT HVGLF IHE J1W KOM M34 M41 MO0 N9A O-L OAUVE OGGZJ OZT P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SPC SPCBC SPT SSM SSP SSZ T5K ~G- .GJ 0R~ AALMO ABFLS ABPIF ABPTK ABQIS ABXDB ADALY AEBSH C45 G-2 GBLVA HZ~ IPNFZ IQODW O9- OVD P-8 RNS SEW TEORI WUQ AAHBH AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX AFJKZ CITATION |
ID | FETCH-LOGICAL-c390t-e654ff0a1a71f34fbdd59eda60b75e627258c5647c79cda9c705cafca76d880c3 |
IEDL.DBID | AIKHN |
ISSN | 0168-3659 |
IngestDate | Thu Sep 26 17:47:08 EDT 2024 Sat Sep 28 07:34:48 EDT 2024 Thu Nov 24 18:30:46 EST 2022 Fri Feb 23 02:29:53 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1-2 |
Keywords | Biodegradation Glycolic acid copolymer Delivery system Injectable form Pharmaceutical technology Control release polymer Review Anhydride polymer Ethylene oxide polymer Anhydride copolymer Triblock copolymer Ester copolymer Lactic acid polymer Dosage form Block copolymer |
Language | English |
License | CC BY 4.0 |
LinkModel | DirectLink |
MeetingName | Special issue: Challenges for drug delivery and pharmaceutical technology |
MergedId | FETCHMERGED-LOGICAL-c390t-e654ff0a1a71f34fbdd59eda60b75e627258c5647c79cda9c705cafca76d880c3 |
PMID | 10518642 |
PageCount | 6 |
ParticipantIDs | crossref_primary_10_1016_S0168_3659_99_00061_9 pubmed_primary_10518642 pascalfrancis_primary_1180603 elsevier_sciencedirect_doi_10_1016_S0168_3659_99_00061_9 |
PublicationCentury | 1900 |
PublicationDate | 1999-11-01 |
PublicationDateYYYYMMDD | 1999-11-01 |
PublicationDate_xml | – month: 11 year: 1999 text: 1999-11-01 day: 01 |
PublicationDecade | 1990 |
PublicationPlace | Amsterdam |
PublicationPlace_xml | – name: Amsterdam – name: Netherlands |
PublicationTitle | Journal of controlled release |
PublicationTitleAlternate | J Control Release |
PublicationYear | 1999 |
Publisher | Elsevier B.V Elsevier |
Publisher_xml | – name: Elsevier B.V – name: Elsevier |
References | Ron, Turner, Mathiowitz, Chasin, Hageman, Langer (BIB8) 1993; 90 Couvreur, Puisieux (BIB11) 1992; 10 Okada, Yamamoto, Heya, Znoue, Kanai, Ogawa, Toguchi (BIB5) 1994; 28 Allcock (BIB12) 1985; 62 Leong, Blott, Langer (BIB7) 1985; 19 Wada, Hyon, Ihada (BIB4) 1990; 79 Kwon, Yokoyama, Okano, Sakurai, Kataoka, Inoue (BIB14) 1990; 11 Cohen, Bano, Visscher, Chow, Allcock, Langer (BIB13) 1990; 112 Youxin, Kissel (BIB15) 1993; 27 B.M. Jeong, Y.H. Bae, S.W. Kim, J. Coilloid Interface Sci., in press. Langer, Peppas (BIB2) 1994; 263 Wuthrich, Ng, Roskos, Heller (BIB6) 1992; 21 Kim, Petersen, Feijen (BIB1) 1980; 5 Lewis (BIB3) 1990; 45 Bennet, Li, Adams, Hoes, Feijen, Kim (BIB10) 1991; 16 Jeong, Lee, Bae, Kim (BIB17) 1997; 388 Private Communication, James Anderson, Case Western Reserve University. Tanodekaew, Godward, Heatley, Booth (BIB19) 1997; 198 Choi, Bae, Kim (BIB16) 1998; 31 Anderson, Fang, Feijen, Gregonis, Kim (BIB9) 1979; 20 Malmsten, Lindman (BIB18) 1992; 25 Bennet (10.1016/S0168-3659(99)00061-9_BIB10) 1991; 16 Jeong (10.1016/S0168-3659(99)00061-9_BIB17) 1997; 388 Kim (10.1016/S0168-3659(99)00061-9_BIB1) 1980; 5 Langer (10.1016/S0168-3659(99)00061-9_BIB2) 1994; 263 Wada (10.1016/S0168-3659(99)00061-9_BIB4) 1990; 79 Cohen (10.1016/S0168-3659(99)00061-9_BIB13) 1990; 112 Malmsten (10.1016/S0168-3659(99)00061-9_BIB18) 1992; 25 Tanodekaew (10.1016/S0168-3659(99)00061-9_BIB19) 1997; 198 Choi (10.1016/S0168-3659(99)00061-9_BIB16) 1998; 31 Leong (10.1016/S0168-3659(99)00061-9_BIB7) 1985; 19 Ron (10.1016/S0168-3659(99)00061-9_BIB8) 1993; 90 Couvreur (10.1016/S0168-3659(99)00061-9_BIB11) 1992; 10 Okada (10.1016/S0168-3659(99)00061-9_BIB5) 1994; 28 Wuthrich (10.1016/S0168-3659(99)00061-9_BIB6) 1992; 21 Allcock (10.1016/S0168-3659(99)00061-9_BIB12) 1985; 62 Lewis (10.1016/S0168-3659(99)00061-9_BIB3) 1990; 45 Youxin (10.1016/S0168-3659(99)00061-9_BIB15) 1993; 27 Anderson (10.1016/S0168-3659(99)00061-9_BIB9) 1979; 20 Kwon (10.1016/S0168-3659(99)00061-9_BIB14) 1990; 11 10.1016/S0168-3659(99)00061-9_BIB20 10.1016/S0168-3659(99)00061-9_BIB21 |
References_xml | – volume: 79 start-page: 919 year: 1990 ident: BIB4 publication-title: J. Pharm. Sci. contributor: fullname: Ihada – volume: 28 start-page: 121 year: 1994 ident: BIB5 publication-title: J. Control. Release contributor: fullname: Toguchi – volume: 90 start-page: 4176 year: 1993 ident: BIB8 publication-title: Proc. Natl. Acad. Sci. contributor: fullname: Langer – volume: 112 start-page: 783 year: 1990 ident: BIB13 publication-title: J. Am. Chem. Soc. contributor: fullname: Langer – volume: 10 start-page: 141 year: 1992 ident: BIB11 publication-title: Adv. Drug Del. Rev. contributor: fullname: Puisieux – volume: 27 start-page: 243 year: 1993 ident: BIB15 publication-title: J. Control. Release contributor: fullname: Kissel – volume: 25 start-page: 5440 year: 1992 ident: BIB18 publication-title: Macromolecules contributor: fullname: Lindman – volume: 62 start-page: 22 year: 1985 ident: BIB12 publication-title: Chem. Eng. News contributor: fullname: Allcock – volume: 5 start-page: 193 year: 1980 ident: BIB1 publication-title: Drug Design contributor: fullname: Feijen – volume: 16 start-page: 43 year: 1991 ident: BIB10 publication-title: J. Control. Release contributor: fullname: Kim – volume: 11 start-page: 269 year: 1990 ident: BIB14 publication-title: J. Control. Release contributor: fullname: Inoue – volume: 45 start-page: 1 year: 1990 ident: BIB3 publication-title: Drug Pharm. Sci. contributor: fullname: Lewis – volume: 21 start-page: 191 year: 1992 ident: BIB6 publication-title: J. Control. Release contributor: fullname: Heller – volume: 20 start-page: 20 year: 1979 ident: BIB9 publication-title: Polymer Preprints contributor: fullname: Kim – volume: 31 start-page: 8766 year: 1998 ident: BIB16 publication-title: Macromolecules contributor: fullname: Kim – volume: 263 start-page: 1715 year: 1994 ident: BIB2 publication-title: Science contributor: fullname: Peppas – volume: 198 start-page: 3385 year: 1997 ident: BIB19 publication-title: Macromol. Chem. Phys. contributor: fullname: Booth – volume: 19 start-page: 941 year: 1985 ident: BIB7 publication-title: J. Biomed. Mater. Res. contributor: fullname: Langer – volume: 388 start-page: 860 year: 1997 ident: BIB17 publication-title: Nature contributor: fullname: Kim – volume: 263 start-page: 1715 year: 1994 ident: 10.1016/S0168-3659(99)00061-9_BIB2 publication-title: Science doi: 10.1126/science.8134835 contributor: fullname: Langer – volume: 79 start-page: 919 year: 1990 ident: 10.1016/S0168-3659(99)00061-9_BIB4 publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600791016 contributor: fullname: Wada – volume: 16 start-page: 43 year: 1991 ident: 10.1016/S0168-3659(99)00061-9_BIB10 publication-title: J. Control. Release doi: 10.1016/0168-3659(91)90029-D contributor: fullname: Bennet – volume: 5 start-page: 193 year: 1980 ident: 10.1016/S0168-3659(99)00061-9_BIB1 contributor: fullname: Kim – volume: 11 start-page: 269 year: 1990 ident: 10.1016/S0168-3659(99)00061-9_BIB14 publication-title: J. Control. Release doi: 10.1016/0168-3659(90)90139-K contributor: fullname: Kwon – volume: 19 start-page: 941 year: 1985 ident: 10.1016/S0168-3659(99)00061-9_BIB7 publication-title: J. Biomed. Mater. Res. doi: 10.1002/jbm.820190806 contributor: fullname: Leong – volume: 10 start-page: 141 year: 1992 ident: 10.1016/S0168-3659(99)00061-9_BIB11 publication-title: Adv. Drug Del. Rev. doi: 10.1016/0169-409X(93)90046-7 contributor: fullname: Couvreur – volume: 62 start-page: 22 year: 1985 ident: 10.1016/S0168-3659(99)00061-9_BIB12 publication-title: Chem. Eng. News doi: 10.1021/cen-v063n011.p022 contributor: fullname: Allcock – volume: 31 start-page: 8766 year: 1998 ident: 10.1016/S0168-3659(99)00061-9_BIB16 publication-title: Macromolecules doi: 10.1021/ma981069i contributor: fullname: Choi – ident: 10.1016/S0168-3659(99)00061-9_BIB21 – volume: 90 start-page: 4176 year: 1993 ident: 10.1016/S0168-3659(99)00061-9_BIB8 publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.90.9.4176 contributor: fullname: Ron – ident: 10.1016/S0168-3659(99)00061-9_BIB20 – volume: 27 start-page: 243 year: 1993 ident: 10.1016/S0168-3659(99)00061-9_BIB15 publication-title: J. Control. Release doi: 10.1016/0168-3659(93)90155-X contributor: fullname: Youxin – volume: 198 start-page: 3385 year: 1997 ident: 10.1016/S0168-3659(99)00061-9_BIB19 publication-title: Macromol. Chem. Phys. doi: 10.1002/macp.1997.021981105 contributor: fullname: Tanodekaew – volume: 20 start-page: 20 year: 1979 ident: 10.1016/S0168-3659(99)00061-9_BIB9 publication-title: Polymer Preprints contributor: fullname: Anderson – volume: 28 start-page: 121 year: 1994 ident: 10.1016/S0168-3659(99)00061-9_BIB5 publication-title: J. Control. Release doi: 10.1016/0168-3659(94)90159-7 contributor: fullname: Okada – volume: 388 start-page: 860 year: 1997 ident: 10.1016/S0168-3659(99)00061-9_BIB17 publication-title: Nature doi: 10.1038/42218 contributor: fullname: Jeong – volume: 112 start-page: 783 year: 1990 ident: 10.1016/S0168-3659(99)00061-9_BIB13 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00177a074 contributor: fullname: Cohen – volume: 25 start-page: 5440 year: 1992 ident: 10.1016/S0168-3659(99)00061-9_BIB18 publication-title: Macromolecules doi: 10.1021/ma00046a049 contributor: fullname: Malmsten – volume: 45 start-page: 1 year: 1990 ident: 10.1016/S0168-3659(99)00061-9_BIB3 publication-title: Drug Pharm. Sci. contributor: fullname: Lewis – volume: 21 start-page: 191 year: 1992 ident: 10.1016/S0168-3659(99)00061-9_BIB6 publication-title: J. Control. Release doi: 10.1016/0168-3659(92)90021-I contributor: fullname: Wuthrich |
SSID | ssj0005347 |
Score | 2.1770468 |
Snippet | Many biodegradable polymers were used for drug delivery and some are successful for human application. There remains fabrication problems, such as difficult... |
SourceID | crossref pubmed pascalfrancis elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 109 |
SubjectTerms | Animals Biocompatible Materials Biodegradation, Environmental Biological and medical sciences Drug Delivery Systems General pharmacology Humans Injections Lactates Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols Polymers Rats Temperature |
Title | New biodegradable polymers for injectable drug delivery systems |
URI | https://dx.doi.org/10.1016/S0168-3659(99)00061-9 https://www.ncbi.nlm.nih.gov/pubmed/10518642 |
Volume | 62 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSyNBEC40uSzIsu7DzbpKH0R2wTE9mX6eRGRDVFaEVfA29FMCkgQTD7nsb7cfE0YFEbwW9IOqnqpvmvq-Bthj2HlizaDAilQFsZgWmpvYNmUIl3yAVSIK_71go2tydkNv1uBkxYWJbZVN7s85PWXrxtJvvNmfjcf9fwGsiIrRgHBSIZbr0A3liJAOdI9Pz0cXbadHRTJrmokiDmiJPHmSZPwl5e80TyFfK1EbMzUPjvP5xYsXODTVo-En-NgASXSc97oJa27yGfYvsxL18gBdtcSq-QHaR5etRvXyCxyF5Ib0eGqjVoSN9Ck0m94t4yU2CjAWjSfxfibZ7f3DLbLuLjZwLFFWfp5_hevhn6uTUdG8pVCYSuJF4Rgl3mNVKl76inhtLZXOKoY1p44N-IAKQxnhhktjlTQcU6O8UZzZ8Imb6ht0JtOJ-w7IVl4pJkqqAtjypRbKCeGt89pZqZnuweHKffUsS2bUT3rJmKijv2sp6-TvWvZArJxcP4t9HdL6W0N3ngWlXbAUmOGqB1s5SE92QksRfrp-vH_RbfiQxBsSI_EndBb3D24nQJOF3oX1w__lbnMAHwHOG99R |
link.rule.ids | 310,311,315,786,790,795,796,4521,23958,23959,24144,25170,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bSxtBFD5YfWihFLW3tFXnoUgLrpnNzvVJRJS0XhAawbdhriUgSTDxIS_97Z3LhsSCFHw97M4M35k959vhfGcAvjLsA3G2V2FNmoo4TCvDbSqbsoRL3sM6C4Uvr1j_hvy8pbdrcLLQwqSyyjb2l5ieo3Vr6bZodifDYfdXJCuiYTQynJyI5QvYSGwg1XUd_lmp82hI0UwzUaXHlzKeMkQ2fpPyex6lkk8lqNcTPY2whXLfxT8sNGejs01409JIdFxWugVrfrQN-9elD_X8AA2WsqrpAdpH18sO1fO3cBRDGzLDsUudIlwST6HJ-G6ejrBRJLFoOEqnM9nu7h9-I-fvUvnGHJW-z9N3cHN2OjjpV-1NCpVtJJ5VnlESAta15nVoSDDOUemdZthw6lmP96iwlBFuubROS8sxtTpYzZmLH7ht3sP6aDzyHwG5JmjNRE11pFqhNkJ7IYLzwXgnDTMdOFzApyalYYZaqSRjQiW8lZQq461kB8QCZPXI8yoG9f-9uvPIKcsJa4EZbjrwoThpZSW0FvGX69PzJ92Dl_3B5YW6-HF1_hle5TYOWZv4BdZn9w9-J5KUmdnNm_AvwdbgJg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=Journal+of+controlled+release&rft.atitle=New+biodegradable+polymers+for+injectable+drug+delivery+systems&rft.au=JEONG%2C+B&rft.au=CHOI%2C+Y.+K&rft.au=BAE%2C+Y.+H&rft.au=ZENTNER%2C+G&rft.date=1999-11-01&rft.pub=Elsevier&rft.issn=0168-3659&rft.eissn=1873-4995&rft.volume=62&rft.issue=1-2&rft.spage=109&rft.epage=114&rft_id=info:doi/10.1016%2FS0168-3659%2899%2900061-9&rft.externalDBID=n%2Fa&rft.externalDocID=1180603 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-3659&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-3659&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-3659&client=summon |