New biodegradable polymers for injectable drug delivery systems

Many biodegradable polymers were used for drug delivery and some are successful for human application. There remains fabrication problems, such as difficult processability and limited organic solvent and irreproducible drug release kinetics. New star-shaped block copolymers, of which the typical mol...

Full description

Saved in:
Bibliographic Details
Published inJournal of controlled release Vol. 62; no. 1-2; pp. 109 - 114
Main Authors Jeong, B., Choi, Y.K., Bae, Y.H., Zentner, G., Kim, S.W.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 01.11.1999
Elsevier
Subjects
Animals
Biocompatible Materials
Biodegradation, Environmental
Biological and medical sciences
Drug Delivery Systems
General pharmacology
Humans
Injections
Lactates
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyethylene Glycols
Polymers
Rats
Temperature
Biodegradation
Glycolic acid copolymer
Delivery system
Injectable form
Pharmaceutical technology
Control release polymer
Review
Anhydride polymer
Ethylene oxide polymer
Anhydride copolymer
Triblock copolymer
Ester copolymer
Lactic acid polymer
Dosage form
Block copolymer
Online AccessGet full text

Cover

More Information
Summary:Many biodegradable polymers were used for drug delivery and some are successful for human application. There remains fabrication problems, such as difficult processability and limited organic solvent and irreproducible drug release kinetics. New star-shaped block copolymers, of which the typical molecular architecture is presented, results from their distinct solution properties, thermal properties and morphology. Their unique physical properties are due to the three-dimensional, hyperbranched molecular architecture and influence microsphere fabrication, drug release and degradation profiles. We recently synthesized thermosensitive biodegradable hydrogel consisting of polyethylene oxide and poly(l-lactic acid). Aqueous solution of these copolymers with proper combination of molecular weights exhibit temperature-dependent reversible sol-gel transition. Desired molecular arrangements provide unique behavior that sol (at low temperature) form gel (at body temperature). The use of these two biodegradable polymers have great advantages for sustained injectable drug delivery systems. The formulation is simple, which is totally free of organic solvent. In sol or aqueous solution state of this polymer solubilized hydrophobic drugs prior to form gel matrix.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(99)00061-9