Recurrent cholestatic jaundice associated with generalized pustular psoriasis: evidence for a neutrophilic cholangitis

• Published in: Journal of hepatology Vol. 33; no. 1; pp. 160 - 162
• Main Authors: Allez, Matthieu, Roux, Marie-Estelle, Bertheau, Philippe, Erlinger, Serge, Degott, Claude, Morel, Patrice, Modigliani, Robert, Rybojad, Michel
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.07.2000; Elsevier
• Subjects: Adult; Biliary tract; Biological and medical sciences; Cholangitis - complications; Cholangitis - pathology; Cholestasis - complications; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Jaundice; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Neutrophilic cholangitis; Neutrophils - pathology; Other diseases. Semiology; Psoriasis - complications; Pustular psoriasis; Recurrence; Syndrome; Biliary tract; Jaundice; Neutrophilic cholangitis; Pustular psoriasis; Bullous dermatosis; Human; Skin disease; Cholangitis; Biliary tract disease; Infection; Case study; Concomitant disease; Cholostasis; Bacteriosis; Digestive diseases; Female; Neutrophil
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/S0168-8278(00)80174-9

Generalized pustular psoriasis can result in systemic complications. We report the case of a woman with relapsing generalized pustular psoriasis and recurring episodes of cholestatic jaundice. Liver biopsy performed during an attack showed a neutrophilic infiltrate surrounding and invading portal triad bile ducts. Ultrasonographic exams and retrograde cholangiography ruled out biliary tract disease. This observation suggests that recurring cholestatic jaundice in pustular psoriasis is related to a neutrophilic cholangitis.