Treatment of Resıstant Cyclophosphamide Induced Haemorrhagic Cystıtıs: Revıew of Literature and Three Case Reports

Haemorrhagic Cystitis (HC) is defined as diffuse inflammatory bladder bleeding due to many aetiologies. Massive HC often arises from anticancer chemotherapy or radiotherapy for the treatment of pelvic malignancies. Phosphamides are the anti-cancer drugs used for treating breast cancer, B-cell lympho...

Full description

Saved in:
Bibliographic Details
Published inJournal of clinical and diagnostic research Vol. 10; no. 4; pp. PD15 - PD16
Main Authors Ebiloglu, Turgay, Kaya, Engin, Yilmaz, Sercan, Özgür, Gökhan, Kibar, Yusuf
Format Journal Article
LanguageEnglish
Published India JCDR Research and Publications (P) Limited 01.04.2016
JCDR Research and Publications Private Limited
Subjects
cidofoxin therapy
clot
haematuria
Surgery Section
Cidofoxin therapy
Haematuria
Clot
Online AccessGet full text

Cover

More Information
Summary:Haemorrhagic Cystitis (HC) is defined as diffuse inflammatory bladder bleeding due to many aetiologies. Massive HC often arises from anticancer chemotherapy or radiotherapy for the treatment of pelvic malignancies. Phosphamides are the anti-cancer drugs used for treating breast cancer, B-cell lymphoma, leukemia, rheumatoid arthritis and systemic lupus erythaematosis by cross-linking strands of DNA and preventing the cell division. They are also used in bone marrow transplantation for prevention of Graft Versus Host Disease (GVHD). Hepatic metabolism of phosphamide forms acrolein, and acrolein makes ulceration, haemorrhage, edema and necrosis of the urothelium during its excretion by the urine. Infectious causes of HC in immunocomprimesed patients are adenovirus, BK polyoma-virus (BK), JC virus, and Cytomegalovirus (CMV). The present article attempts to make a review of literature for the treatment of intractable HC and report three cases with HC.
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2016/16948.7642