Clinical usefulness of saphenous vein graft in major arterial reconstruction during extended pancreatectomy

• Published in: Langenbeck's archives of surgery Vol. 405; no. 7; pp. 1051 - 1059
• Main Authors: Kimura, Yasutoshi, Imamura, Masafumi, Kuroda, Yosuke, Nagayama, Minoru, Itoh, Tatsuya, Oota, Shigenori, Murakami, Takeshi, Yamaguchi, Hiroshi, Nobuoka, Takayuki, Kawaharada, Nobuyoshi, Takemasa, Ichiro
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2020
• Subjects: Abdominal Surgery; Cardiac Surgery; General Surgery; How-I-Do-It articles; Medicine; Medicine & Public Health; Thoracic Surgery; Traumatic Surgery; Vascular Surgery; Arterial reconstruction; Non-anatomical; Great saphenous vein; Pancreatectomy
• ISSN: 1435-2443; 1435-2451
• DOI: 10.1007/s00423-020-01947-3

Purpose Extended pancreatectomy for locally advanced pancreatobiliary malignancy often involves combined major arterial resection (AR) and reconstruction (ARc). By limiting candidate inflow for ARc after combined resection of the celiac arterial system over a long distance, we evaluated whether great saphenous vein graft (GSVG) is an alternative conduit for obtaining non-anatomical arterial inflow. Methods ARc with GSVG conduit was undertaken prior to resection. GSVG was harvested and anastomosed end-to-side with the reconstructing artery and then mostly passed via the retroperitoneal para-inferior vena cava route. Side-to-end anastomosis of GSVG inflow was established with the right common iliac artery or abdominal aorta. Results Among 468 consecutive pancreatobiliary surgeries, ARc with GSVG was undertaken in seven cases. Primary cancers were in the pancreas in six patients and distal bile duct in one. Radical surgery was performed with pancreaticoduodenectomy in six patients and total pancreatectomy in one. Hepatic artery (HA) was concomitantly resected and reconstructed by GSVG in six patients or by the jejunal artery in one patient. Median operative time and intraoperative blood loss were 763 min and 350 ml, respectively. Serum level of AST, ALT, and LDH in patients with HA reconstruction by GSVG peaked by the second postoperative day and promptly normalized. Postoperative morbidity (CD ≥ III) was encountered in one patient. No surgical mortality was observed. Postoperative serum liver enzymes promptly decreased in ARc patients with GSVG to HA. Conclusion Arterial reconstruction with GSVG prior to resection was performed securely and might help to reduce postoperative liver dysfunction.