Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles

• Published in: European journal of medicinal chemistry Vol. 43; no. 6; pp. 1152 - 1159
• Main Authors: Scholz, Michael, Ulbrich, Holger K., Dannhardt, Gerd
• Format: Journal Article
• Language: English
• Published: PARIS Elsevier Masson SAS 01.06.2008; Elsevier
• Subjects: 5-LOX; Azoles - chemistry; Azoles - pharmacology; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Chemistry, Medicinal; COX-1/2; Cyclooxygenase Inhibitors - chemistry; Cyclooxygenase Inhibitors - pharmacology; Dual inhibitors; Free Radical Scavengers - chemistry; Free Radical Scavengers - pharmacology; Hydroxyl radical scavenging; Isoselenazoles; Life Sciences & Biomedicine; Lipoxygenase Inhibitors - chemistry; Lipoxygenase Inhibitors - pharmacology; Magnetic Resonance Spectroscopy; Medical sciences; Models, Molecular; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Science & Technology; Selenium Compounds - chemistry; Selenium Compounds - pharmacology; Isoselenazoles; Hydroxyl radical scavenging; 5-LOX; Dual inhibitors; COX-1/2; OXIDATIVE DAMAGE; COX-2; dual inhibitors; isoselenazoles; 5-LOX INHIBITORS; CYCLOOXYGENASE INHIBITORS; hydroxyl radical scavenging; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTIOXIDANT; EBSELEN; 5-LIPOXYGENASE; INSIGHTS; Prostaglandin-endoperoxide synthase; Enzyme; Cyclooxygenase 2; Cyclooxygenase 1; Enzyme inhibitor; Ebselen; Celecoxib; Antioxidant; In vitro; Radical scavenger; Biological activity; Non steroidal antiinflammatory agent; Arachidonate 5-lipoxygenase; Oxidoreductases; Chemical synthesis; Hydroxyl
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2007.09.007

The aim of this study was to investigate 4,5-diaryl isoselenazoles as multiple target non-steroidal anti-inflammatory drugs (MTNSAIDs) which can intervene into the inflammatory processes via different mechanisms of action creating a new class of compounds. Here we describe the synthesis of COX/LOX inhibitors which additionally reduce the level of reactive oxygen species, such as hydroxyl radicals which are well known for supporting inflammation processes in Parkinson's disease, Alzheimer's disease and rheumatoid arthritis. [Display omitted]