Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen

Early treatment with ibuprofen for a large patent ductus arteriosus did not result in a lower risk of death or moderate or severe bronchopulmonary dysplasia than placebo at 36 weeks of postmenstrual age.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 390; no. 4; pp. 314 - 325
Main Authors Gupta, Samir, Subhedar, Nimish V., Bell, Jennifer L., Field, David, Bowler, Ursula, Hutchison, Elizabeth, Johnson, Sam, Kelsall, Wilf, Pepperell, Justine, Roberts, Tracy, Sinha, Sunil, Stanbury, Kayleigh, Wyllie, Jonathan, Hardy, Pollyanna, Juszczak, Edmund
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 25.01.2024
Subjects
Age
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Bronchopulmonary Dysplasia - etiology
Bronchopulmonary Dysplasia - mortality
Cardiology
Cardiology General
Childhood Diseases
Clinical trials
Confidence intervals
Congenital diseases
Congenital Heart Disease
Coronary vessels
Cyclooxygenase Inhibitors - administration & dosage
Cyclooxygenase Inhibitors - adverse effects
Cyclooxygenase Inhibitors - therapeutic use
Double-Blind Method
Ductus Arteriosus, Patent - complications
Ductus Arteriosus, Patent - drug therapy
Ductus Arteriosus, Patent - mortality
Dysplasia
Gestational age
Hemorrhage
Humans
Ibuprofen
Ibuprofen - administration & dosage
Ibuprofen - adverse effects
Ibuprofen - therapeutic use
Infant, Extremely Premature
Infant, Newborn
Infants
Lung diseases
Mortality
Multiple births
Neonates
Neonatology
Newborn babies
Nonsteroidal anti-inflammatory drugs
Pediatrics
Pediatrics General
Placebos
Premature babies
Prostaglandin endoperoxide synthase
Pulmonary hypertension
Statistical analysis
Technology assessment
Time Factors
Treatment Outcome
United Kingdom > UK
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More Information
Summary:Early treatment with ibuprofen for a large patent ductus arteriosus did not result in a lower risk of death or moderate or severe bronchopulmonary dysplasia than placebo at 36 weeks of postmenstrual age.
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2305582