PARPs and ADP-ribosylation: 60 years on

Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts o...

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Bibliographic Details
Published inGenes & development Vol. 34; no. 5-6; pp. 251 - 253
Main Author Kraus, W Lee
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.03.2020
Subjects
PARPs
posttranslational modification
ADP-ribosylation
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Summary:Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.336420.120