Microcolumn size-exclusion chromatography coupled with electrospray ionization mass spectrometry

Microcolumn (250×0.5 mm I.D.) size-exclusion chromatography was implemented for the separation of polydisperse mixtures prior to electrospray ionization (ESI) mass spectrometric detection. An improved separation, compared to conventional-bore SEC, was demonstrated upon coupling with ESI quadrupole i...

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Published inJournal of Chromatography A Vol. 835; no. 1; pp. 121 - 126
Main Authors Prokai, Laszlo, Aaserud, David J, Simonsick, William J
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 12.03.1999
Elsevier
Subjects
Applied sciences
Chromatography, Gel - instrumentation
Exact sciences and technology
Fourier Analysis
Mass Spectrometry - instrumentation
Octoxynol - chemistry
Octylphenoxypoly(ethoxy)ethanol
Organic polymers
Physicochemistry of polymers
Polymers
Properties and characterization
Structure, morphology and analysis
Size-exclusion chromatography
Liquid chromatography–mass spectrometry
Polymers
Octylphenoxypoly(ethoxy)ethanol
Ethylene oxide polymer
Ion trap
Molecular weight distribution
Coupled method
Oligomer
Mass spectrometry
Electrospray
Gel permeation chromatography
Microbore column
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Summary:Microcolumn (250×0.5 mm I.D.) size-exclusion chromatography was implemented for the separation of polydisperse mixtures prior to electrospray ionization (ESI) mass spectrometric detection. An improved separation, compared to conventional-bore SEC, was demonstrated upon coupling with ESI quadrupole ion-trap mass spectrometry and a Fourier transform ion cyclotron resonance instrument for the separation of individual oligomers present in octylphenoxypoly(ethoxy)ethanol.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9673
DOI:10.1016/S0021-9673(98)01082-6