Diverting colostomy is an effective and reversible option for severe hemorrhagic radiation proctopathy

• Published in: World journal of gastroenterology : WJG Vol. 26; no. 8; pp. 850 - 864
• Main Authors: Yuan, Zi-Xu, Qin, Qi-Yuan, Zhu, Miao-Miao, Zhong, Qing-Hua, Fichera, Alessandro, Wang, Hui, Wang, Huai-Ming, Huang, Xiao-Yan, Cao, Wu-Teng, Zhao, Ye-Biao, Wang, Lei, Ma, Teng-Hui
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.02.2020
• Subjects: Aged; Colostomy - methods; Female; Gastrointestinal Hemorrhage - etiology; Gastrointestinal Hemorrhage - surgery; Humans; Male; Middle Aged; Observational Study; Quality of Life; Radiation Injuries - etiology; Radiation Injuries - surgery; Rectal Diseases - etiology; Rectal Diseases - surgery; Rectum - surgery; Retrospective Studies; Surgical Stomas; Treatment Outcome; Chronic radiation proctitis; Colostomy; Hemorrhage; Anorectal function; Quality of life
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v26.i8.850

Severe chronic radiation proctopathy (CRP) is difficult to treat. To evaluate the efficacy of colostomy and stoma reversal for CRP. To assess the efficacy of colostomy in CRP, patients with severe hemorrhagic CRP who underwent colostomy or conservative treatment were enrolled. Patients with tumor recurrence, rectal-vaginal fistula or other types of rectal fistulas, or who were lost to follow-up were excluded. Rectal bleeding, hemoglobin (Hb), endoscopic features, endo-ultrasound, rectal manometry, and magnetic resonance imaging findings were recorded. Quality of life before stoma and after closure reversal was scored with questionnaires. Anorectal functions were assessed using the CRP symptom scale, which contains the following items: Watery stool, urgency, perianal pain, tenesmus, rectal bleeding, and fecal/gas incontinence. A total of 738 continual CRP patients were screened. After exclusion, 14 patients in the colostomy group and 25 in the conservative group were included in the final analysis. Preoperative Hb was only 63 g/L ± 17.8 g/L in the colostomy group compared to 88.2 g/L ± 19.3 g/L ( < 0.001) in the conservative group. All 14 patients in the former group achieved complete remission of bleeding, and the colostomy was successfully reversed in 13 of 14 (93%), excepting one very old patient. The median duration of stoma was 16 (range: 9-53) mo. The Hb level increased gradually from 75 g/L at 3 mo, 99 g/L at 6 mo, and 107 g/L at 9 mo to 111 g/L at 1 year and 117 g/L at 2 years after the stoma, but no bleeding cessation or significant increase in Hb levels was observed in the conservative group. Endoscopic telangiectasia and bleeding were greatly improved. Endo-ultrasound showed decreased vascularity, and magnetic resonance imaging revealed an increasing presarcal space and thickened rectal wall. Anorectal functions and quality of life were significantly improved after stoma reversal, when compared to those before stoma creation. Diverting colostomy is a very effective method in the remission of refractory hemorrhagic CRP. Stoma can be reversed, and anorectal functions can be recovered after reversal.