Contractile effect of the aqueous extract of Psidium guajava leaves on aortic rings in rat

• Published in: Fitoterapia Vol. 78; no. 3; pp. 241 - 243
• Main Authors: Olatunji-Bello, I.I., Odusanya, A.J., Raji, I., Ladipo, C.O.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2007; Elsevier
• Subjects: Animals; Aorta; Aorta - drug effects; Biological and medical sciences; Contractility; General pharmacology; Medical sciences; Muscle Contraction - drug effects; Muscle, Smooth, Vascular - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Leaves; Psidium; Psidium guajava; Rats; Rats, Sprague-Dawley; Vascular smooth muscle; Vasodilator Agents - administration & dosage; Vasodilator Agents - pharmacology; Vasodilator Agents - therapeutic use; Aorta; Vascular smooth muscle; Psidium guajava; Contractility; Rat; Pharmacognosy; Rodentia; Smooth muscle; Extract; Plant leaf; Artery; Medicinal plant; Vertebrata; Mammalia; Dicotyledones; Animal; Blood vessel; Angiospermae; Plant origin; Myrtaceae; Spermatophyta; Circulatory system; Fruit tree
• ISSN: 0367-326X
• DOI: 10.1016/j.fitote.2006.11.007

Aqueous leaves extract of Psidium guajava significantly and dose-dependently (0.25–2 mg/ml) contracted aorta rings. The effect was evaluated also in presence of nifedipine and phentolamine. The sensitivity of the aortic rings to cumulative doses of P. guajava was significantly enhanced in the presence of phentolamine suggesting that the effect of P. guajava was to a large extent mediated by activation of α-adrenoceptor and to a lesser extent by acting via calcium ion channel.