Changes of Chromosomes 1, 3, 6, and 11 in Metastatic Effusions Arising from Breast and Ovarian Cancer

• Published in: Cancer genetics and cytogenetics Vol. 110; no. 1; pp. 34 - 40
• Main Authors: Ioakim-Liossi, Anna, Gagos, Sarantis, Athanassiades, Petros, Athanassiadou, Paulina, Gogas, John, Davaris, Panagiotis, Markopoulos, Christos
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1999; Elsevier Science
• Subjects: Adult; Aged; Ascitic Fluid - genetics; Biological and medical sciences; Breast Neoplasms - genetics; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 6; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Middle Aged; Ovarian Neoplasms - genetics; Pleural Effusion - genetics; Tumors; Chromosomal aberration; Human; Carcinoma; Respiratory disease; Aneuploidy; Malignant tumor; Female genital diseases; Mammary gland diseases; Ovarian diseases; Ovary; Abdominal disease; Malignant effusion; Cytogenetics; Pleural disease; Mammary gland; Ascites; Pleura
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/S0165-4608(98)00172-1

This cytogenetic study deals with cell material obtained from 15 pleural fluids from 11 patients with breast cancer and 27 ascitic fluids from 16 patients with ovarian cancer; in addition, 8 pleural, 5 ascitic, and 1 pericardial fluid from patients with tuberculosis, liver cirrhosis, and heart insufficiency, were studied. Using mainly direct methods, as well as short-term cell cultures, the chromosome spreads were GTG-banded. Cancerous biopsies showed a plethora of numerical and structural chromosome anomalies and exhibited broad aneuploidy. Chromosomes participating more often in numerical and structural aberrations were 1, 3, 6, 7, 8, 9, 11, 12, and 17. This study provides further cytogenetic evidence for the involvement of these chromosomes in breast and ovarian malignancy.