Immunocytochemical staining of astrocytes, tanycytes, immature glial cells and ependymal cells in the central nervous system of the normal rat and the myelin-deficient mutant

Central nervous system (CNS) tissue from young myelin-deficient (md) mutant rats and male littermate controls was immunostained with antibodies against the following glial-cell antigens: glial fibrillary acidic protein (GFAP), glutamine synthetase, vimentin, the Yb isozyme of glutathione-S-transfera...

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Bibliographic Details
Published inDevelopmental neuroscience Vol. 11; no. 2; p. 90
Main Authors Cammer, W, Tansey, F A
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1989
Subjects
Animals
Central Nervous System - metabolism
Central Nervous System - pathology
Demyelinating Diseases - pathology
Ependyma - metabolism
Ependyma - pathology
Glial Fibrillary Acidic Protein - analysis
Glutamate-Ammonia Ligase - metabolism
Neuroglia - metabolism
Neuroglia - pathology
Rats
Rats, Inbred Strains
Vimentin - metabolism
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Summary:Central nervous system (CNS) tissue from young myelin-deficient (md) mutant rats and male littermate controls was immunostained with antibodies against the following glial-cell antigens: glial fibrillary acidic protein (GFAP), glutamine synthetase, vimentin, the Yb isozyme of glutathione-S-transferase (Yb) and carbonic anhydrase. Gliosis was most severe in spinal-cord 'white-matter' tracts in the md rat. The most dramatic differences between astrocytes in the md and normal animals were revealed with anti-GFAP and anti-vimentin. Ependymal cells and tanycytes were quite similar in the md and normal CNS. Among the glial-cell antigens, Yb showed the broadest distribution, which included astrocytes, ependymal cells and tanycytes.
ISSN:0378-5866
DOI:10.1159/000111890