New malonylginsenosides from the fresh fruits of Panax notoginseng

Four new malonylginsenosides, malonylnotoginsenoside Fe (1), malonylnotoginsenoside Ra1 (2), malonylgypenoside LXXV (3), and malonylginsenoside Mc (4), together with two known analogues, malonylfloralginsenoside Rc1 (5) and malonylginsenoside Rc (6), were isolated from the fresh fruits of Panax noto...

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Published inFitoterapia Vol. 150; p. 104844
Main Authors Qu, Zheng-Yi, Zong, Yu, Zheng, Pei-He, Jin, Yin-Ping, Li, Wei, Wang, He-Cheng, Li, Ya-Li, Wang, Ying-Ping
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2021
Elsevier Science Ltd
Subjects
Cytotoxicity
Fruits
Malonylginsenosides
NMR
Nuclear magnetic resonance
Panax notoginseng
Panax notoginseng
Cytotoxicity
NMR
Fruits
Malonylginsenosides
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Summary:Four new malonylginsenosides, malonylnotoginsenoside Fe (1), malonylnotoginsenoside Ra1 (2), malonylgypenoside LXXV (3), and malonylginsenoside Mc (4), together with two known analogues, malonylfloralginsenoside Rc1 (5) and malonylginsenoside Rc (6), were isolated from the fresh fruits of Panax notoginseng. Their structures were determined by MS and NMR experiments. The anti-proliferative activities of the malonylginsenosides (1–6) against SH-SY5Y human neuroblastoma cell line were evaluated using the MTT assay. [Display omitted] •Four new malonylginsenosides, together with two known analogues were isolated from the fresh fruits of Panax notoginseng.•This was the first report that malonylginsenosides (2–4) can be directly acylated on the sapogenin moiety.•The cytotoxic activity of six malonylginsenosides were also evaluated.
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2021.104844