Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis

• Published in: European journal of pharmacology Vol. 590; no. 1; pp. 387 - 395
• Main Authors: Kamath, Burde Sandesh, Srikanta, Belagihally Manjegowda, Dharmesh, Shylaja Mallaiah, Sarada, Ravi, Ravishankar, Gokare Aswathanarayana
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 20.08.2008; Elsevier
• Subjects: Animals; Anti-Ulcer Agents - pharmacology; Antioxidant; Antioxidants - pharmacology; Astaxanthin; Biological and medical sciences; Carotenoids - isolation & purification; Carotenoids - pharmacology; Chlorophyta - chemistry; Female; Gastric Mucosa - pathology; Gastroprotective; Haematococcus; Lipid Peroxidation - drug effects; Lipoxygenase Inhibitors - pharmacology; Male; Medical sciences; Pharmacology. Drug treatments; Proton Pump Inhibitors; Rats; Rats, Wistar; Stomach Ulcer - prevention & control; Xanthophylls - isolation & purification; Xanthophylls - pharmacology; Haematococcus; Gastroprotective; Antioxidant; Astaxanthin; Prevention; Ulcer

The anti-ulcer properties of astaxanthin fractions such as total carotenoid and astaxanthin esters from Haematococcus pluvialis were evaluated in ethanol-induced gastric ulcers in rats. Since oxygen radical release is a pathogenic factor of ethanol-induced gastric damage, astaxanthin — a free radica...