Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years
Cardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined. Cineventriculograms of 3436 were analyzed for presence of regional function impairment as sign of MI. Genotyping for genetic polymorphism (vitami...
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Published in | International journal of cardiology Vol. 105; no. 1; pp. 90 - 95 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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20.10.2005
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Abstract | Cardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined.
Cineventriculograms of 3436 were analyzed for presence of regional function impairment as sign of MI. Genotyping for genetic polymorphism (vitamin D receptor
VDR BsmI, interleukin-6
IL6-174 G/C, chemokine receptor 2
CCR2 64 V/I) was performed. CRF were assessed (hypertension, hypercholesterolemia, smoking, and diabetes mellitus).
In patients <
65 years (
n
=
1946) genotypes (VDR BB, IL6 GC/CC, CCR2 VI/II, defined as GRF) were significantly associated with the presence of MI (BB: OR 1.38, 95%CI 1.07–1.79,
p
=
0.016 GC/CC: 1.28, 95%CI 1.03–1.60,
p
=
0.028 VI/II: 1.49, 95%CI 1.17–1.88,
p
=
0.001). Combining four CRF (14% vs. 21% vs. 27% vs. 31% vs. 38%,
p
<
0.0001) and three GRF (21% vs. 25% vs. 32% vs. 44%,
p
<
0.0001) revealed additive effects on the prevalence of MI. The more combined CRF and GRF were present (from 0 to 7) the higher was the prevalence of MI (11% vs. 12% vs. 21% vs. 27% vs. 30% vs. 34% vs. 59%,
p
<
0.0001). Age was not associated with MI. In patients ≥
65 years (
n
=
1490) the combination of CRF was only weakly associated with MI, while GRF were not. In these patients age was a predictor of MI.
Certain GRF might have additive but small effects on the disposition for MI before the age of 65. In older patients the tested GRF had no effect, possibly indicating a mechanism of aging rather than a purely genetic determined entity. Given the small effect of the tested genetic polymorphisms the value of testing GRF remains uncertain. |
---|---|
AbstractList | Cardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined.
Cineventriculograms of 3436 were analyzed for presence of regional function impairment as sign of MI. Genotyping for genetic polymorphism (vitamin D receptor
VDR BsmI, interleukin-6
IL6-174 G/C, chemokine receptor 2
CCR2 64 V/I) was performed. CRF were assessed (hypertension, hypercholesterolemia, smoking, and diabetes mellitus).
In patients <
65 years (
n
=
1946) genotypes (VDR BB, IL6 GC/CC, CCR2 VI/II, defined as GRF) were significantly associated with the presence of MI (BB: OR 1.38, 95%CI 1.07–1.79,
p
=
0.016 GC/CC: 1.28, 95%CI 1.03–1.60,
p
=
0.028 VI/II: 1.49, 95%CI 1.17–1.88,
p
=
0.001). Combining four CRF (14% vs. 21% vs. 27% vs. 31% vs. 38%,
p
<
0.0001) and three GRF (21% vs. 25% vs. 32% vs. 44%,
p
<
0.0001) revealed additive effects on the prevalence of MI. The more combined CRF and GRF were present (from 0 to 7) the higher was the prevalence of MI (11% vs. 12% vs. 21% vs. 27% vs. 30% vs. 34% vs. 59%,
p
<
0.0001). Age was not associated with MI. In patients ≥
65 years (
n
=
1490) the combination of CRF was only weakly associated with MI, while GRF were not. In these patients age was a predictor of MI.
Certain GRF might have additive but small effects on the disposition for MI before the age of 65. In older patients the tested GRF had no effect, possibly indicating a mechanism of aging rather than a purely genetic determined entity. Given the small effect of the tested genetic polymorphisms the value of testing GRF remains uncertain. BACKGROUNDCardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined.METHODSCineventriculograms of 3436 were analyzed for presence of regional function impairment as sign of MI. Genotyping for genetic polymorphism (vitamin D receptor VDR BsmI, interleukin-6 IL6-174 G/C, chemokine receptor 2 CCR2 64 V/I) was performed. CRF were assessed (hypertension, hypercholesterolemia, smoking, and diabetes mellitus).RESULTSIn patients <65 years (n=1946) genotypes (VDR BB, IL6 GC/CC, CCR2 VI/II, defined as GRF) were significantly associated with the presence of MI (BB: OR 1.38, 95%CI 1.07-1.79, p=0.016 GC/CC: 1.28, 95%CI 1.03-1.60, p=0.028 VI/II: 1.49, 95%CI 1.17-1.88, p=0.001). Combining four CRF (14% vs. 21% vs. 27% vs. 31% vs. 38%, p<0.0001) and three GRF (21% vs. 25% vs. 32% vs. 44%, p<0.0001) revealed additive effects on the prevalence of MI. The more combined CRF and GRF were present (from 0 to 7) the higher was the prevalence of MI (11% vs. 12% vs. 21% vs. 27% vs. 30% vs. 34% vs. 59%, p< 0.0001). Age was not associated with MI. In patients > or =65 years (n=1490) the combination of CRF was only weakly associated with MI, while GRF were not. In these patients age was a predictor of MI.CONCLUSIONCertain GRF might have additive but small effects on the disposition for MI before the age of 65. In older patients the tested GRF had no effect, possibly indicating a mechanism of aging rather than a purely genetic determined entity. Given the small effect of the tested genetic polymorphisms the value of testing GRF remains uncertain. Cardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined. Cineventriculograms of 3436 were analyzed for presence of regional function impairment as sign of MI. Genotyping for genetic polymorphism (vitamin D receptor VDR BsmI, interleukin-6 IL6-174 G/C, chemokine receptor 2 CCR2 64 V/I) was performed. CRF were assessed (hypertension, hypercholesterolemia, smoking, and diabetes mellitus). In patients <65 years (n=1946) genotypes (VDR BB, IL6 GC/CC, CCR2 VI/II, defined as GRF) were significantly associated with the presence of MI (BB: OR 1.38, 95%CI 1.07-1.79, p=0.016 GC/CC: 1.28, 95%CI 1.03-1.60, p=0.028 VI/II: 1.49, 95%CI 1.17-1.88, p=0.001). Combining four CRF (14% vs. 21% vs. 27% vs. 31% vs. 38%, p<0.0001) and three GRF (21% vs. 25% vs. 32% vs. 44%, p<0.0001) revealed additive effects on the prevalence of MI. The more combined CRF and GRF were present (from 0 to 7) the higher was the prevalence of MI (11% vs. 12% vs. 21% vs. 27% vs. 30% vs. 34% vs. 59%, p< 0.0001). Age was not associated with MI. In patients > or =65 years (n=1490) the combination of CRF was only weakly associated with MI, while GRF were not. In these patients age was a predictor of MI. Certain GRF might have additive but small effects on the disposition for MI before the age of 65. In older patients the tested GRF had no effect, possibly indicating a mechanism of aging rather than a purely genetic determined entity. Given the small effect of the tested genetic polymorphisms the value of testing GRF remains uncertain. |
Author | Kimmel, Melanie Ortlepp, Jan R. Vesper, Katharina Mevissen, Vera Janssens, Uwe Franke, Andreas von Korff, Alexei Schmitz, Fabian Hanrath, Peter Krantz, Constanze Zerres, Klaus Hoffmann, Rainer |
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Keywords | Myocardial infarction Cardiovascular risk factors Genetic polymorphism Genetic risk factors Human Prevalence Cardiovascular disease Chemokine receptor jenetic risk factors Epidemiology Myocardial disease Phlebology Vascular disease Interleukin 2 Vitamin D Heart disease Atherosclerosis Risk factor Genetics Circulatory system Cardiology Polymorphism Biological receptor |
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Snippet | Cardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains undetermined.... BACKGROUNDCardiovascular risk factors (CRF) have been associated with myocardial infarction (MI), while the role of genetic risk factors (GRF) remains... |
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SubjectTerms | Age Factors Aged Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - genetics Cardiovascular risk factors Coronary heart disease Female Gene Frequency Genetic polymorphism Genetic Predisposition to Disease - genetics Genetic risk factors Genotype Heart Humans Interleukin-6 - genetics Male Medical sciences Middle Aged Myocardial infarction Myocardial Infarction - genetics Myocarditis. Cardiomyopathies Phenotype Polymorphism, Genetic - genetics Receptors, Calcitriol - genetics Receptors, CCR2 Receptors, Chemokine - genetics Risk Factors |
Title | Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years |
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